In this paper, we established magnetic fluid hyperthermia (MFH) model for rat tumor using the finite element software COMSOL based on the linear response theory. By analyzing four kinds of magnetic medium within relaxation mechanism, such as Fe3O4、FeCo、fccFePt and L10FePt, we studied the influence of the change of magnetic medium radius on dissipation power and temperature field, respectively. At the same time, the optimization method for the parameters of several magnetic medium is proposed, and the applications of four kinds of magnetic medium are given as well. By increasing the dissipation power of the magnetic medium as much as possible, the dose of magnetic medium used in the treatment can be reduced, meanwhile, the adverse effects on health tissue surrounding the tumor will be minimized. The conclusions of this paper can provide reference for magnetic medium preparation applied to MFH.
Ischemic stroke (IS) is one of the important diseases threatening human health. The occurrence and development of IS can trigger a series of complex pathophysiological changes, including damage to the blood-brain barrier, ion imbalance, oxidative stress, mitochondrial damage, which ultimately lead to the apoptosis and necrosis of nerve cells in the ischemic area. Impaired blood-brain barrier is a key factor for cerebral edema, hemorrhagic transformation and poor prognosis in patients with IS, and neuroinflammatory response plays an important role in the damage and repair of the blood-brain barrier. This article mainly focuses on the neuroinflammatory response mediated by glial cells, pro-inflammatory cytokines and matrix metalloproteinases and the related mechanisms of IS blood-brain barrier damage and repair, in order to provide new directions for the treatment of IS.