ObjectiveTo study the short-and long-term outcomes of high platelet count in patients with colorectal cancer after surgery. MethodsA total of 398 patients with colorectal cancer who complied with the requirements for this study and operated in professional group on colorectal surgery of Gastrointestinal Surgery Center of West China Hospital in Sichuan University from January 2009 to October 2009 were retrospectively included in this study. Based on the last preoperative platelet count, these patients were divided into normal platelet group(100×109/L-300×109/L)and high platelet group( > 300×109/L). The short-and long-term outcomes were analyzed and compared between two groups. Results①The gender, age, histological type, degree of differentiation, diameter of tumor, site of tumor, and operation method had no significant differences between two groups(P > 0.05), but the ratio ofⅢ, Ⅳstages of TNM in the high platelet group was significantly higher than that in the normal platelet group(P < 0.05).②The first exhaust time and defecation time of the normal platelet group was significantly shorter than those of the high platelet group(P < 0.05). The time of the first oral intake, the time of pull out the drainage, ureter, and nasogastric tube, the time of the first ambulation, and hospitalstay had no significant differences between two groups(P > 0.05).③The total complications rate and single complication rate had no significant differences between two groups(P > 0.05).④All the patients were followed-up with average following-up time 58 months, there were 7 patients with recurrence and 35 patients with death in all the followed-up patients, the recurrence rate and death rate in the high platelet group were significantly higher than those in the normal platelet group(3.5% versus 1.1%, P=0.013; 15.7% versus 6.0%, P=0.002). ConclusionsThere is a relationship of platelet count to colorectal malignant degree. The recovery time of gastrointestinal function is longer, and the local recurrence rate and the postoperative death rate are higher for the patients with high platelet count.
ObjectivesTo explore the predictive value of platelet count at admission for long-term prognosis in patients with type B acute aortic dissection (AAD) undergoing endovascular therapy (EVT). MethodsWe investigated 131 consecutive patients with type B AAD after EVT in West China Hospital of Sichuan University from January to December 2012. The patients’ basic clinical data, blood test results, major adverse cardiovascular events, and in-hospital and out-hospital survival status were collected. According to the tri-sectional quantiles of platelet counts, the patients were divided into three groups. Chi-square test was used to analyze the correlation between platelet count and hospital complications. Kaplan-Meier survival analysis and Cox regression analysis were used to analyze the relationship between platelet count and survival in patients with type B AAD. The primary endpoint was all-cause death. ResultsThe overall in-hospital mortality of the 131 patients was 9.9%, and the mortality was 16.0% by the end of the follow-up, the median length of which was 2.1 years. There were 44 cases in T1 group (platelet count >200×10 9/L), 44 cases in T2 group [platelet count (155–200)×109/L], and 43 cases in T3 group [platelet count ≤155×109/L]. The mortality in T3 group (30.2%) was higher than that in T1 group (4.5%) and T2 group (13.6%) (P=0.004). Kaplan-Meier survival analysis showed that the cumulative survival rate of T3 group was significantly lower than that of T1 group and T2 group (69.8% vs. 95.5%, χ2=10.165, P=0.001; 69.8% vs. 86.4%, χ2=5.174, P=0.037). Cox multivariate analysis showed that age [hazard ratio (HR)=1.043, 95% confidence interval (CI) (1.009, 1.079), P=0.013], heart rate [HR=1.030, 95%CI (1.004, 1.058), P=0.024], and platelet count [HR=6.011, 95%CI (1.319, 27.391), P=0.020] were independent risk factors for mortality. Older age, rapid heart rate, and lower platelet count would increase the risk of death. ConclusionPlatelet count may be an independent factor that affects the prognosis of patients with type B AAD after EVT, and a low platelet count at admission increases the risk of death.