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find Keyword "Reverse transcription- polymerase chain reaction Foundation item" 1 results
  • TRANSFORMING GROWTH FACTOR β 1 AND INTERLEUKIN 6 mRNA EXPRESSION IN WOUND TISSUES OF PATIENTS WITH DIABETIC ULCERS

    OBJECTIVE To study the relationship between the changes of mRNA expression in wound tissues of diabetic ulcers and tissue repair. METHODS The mRNA expression of TGF-beta 1 and IL-6 in eight bioptic samples of diabetic ulcers were detected by RT-PCR and pathologic methods, and the surrounding normal skins from the same patients were measured as control group. RESULTS The mRNA expression levels of TGF-beta 1 were markedly decreased in the diabetic ulcers compared with control group, while the mRNA expression levels of IL-6 were increased at the same reaction conditions. CONCLUSION The different changes of mRNA expression level of TGF-beta 1 and IL-6 in wound tissue result in low production and decreased activity of TGF-beta 1 and IL-6, which lower the reparative ability of wound tissue.

    Release date:2016-09-01 11:05 Export PDF Favorites Scan
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