Objective To investigate the efficacy and the safety of external therapy of ultrasound (ETUS) enhancing thrombolysis on the experimental retinal vein occlusion. Methods The effect of ETUS enhanced thrombolysis and the impact of ultrasound energy and exposure were investigated respectively after both eyes of 51 rabbits with retinal branch vein occlusion created by photodynamic initiated thrombosis were divided into 4 groups. The first 2 groups are the ETUS groups, including one group (15 rabbits) underwent intravenous injection with urokinase (UK) (1700-2200 UK dissolved into 20 ml normal saline), and other group (12 rabbits) underwent intravenous injection with normal saline. In these 2 groups, each rabbit received ETUS treatment (1.0 W/cm2, 20 min) in one eye and the fellow eye did not which was as the control. The latter 2 groups are the energy and duration of ultrasound groups, and 12 rabbits in each group underwent ETUS with the energy of 0.7 and 1.0 W/cm2 respectively. Each of the 2 groups was divided into 3 subgroups (8 rabbits in each) according to the radiated durations (8, 14, and 20 minutes). All of the eyes except the control ones underwent ETUS with 1 MHz ultrasound and 100 Hz pulsed ultrasound once a day for 3 days. Fundus fluorescein angiography (FFA) was used to detect the vascular condition 4 days after ETUS, and at the 15th day, retinal light microscopy and electron microscopy were performed. Results The vascular recanalization rate in ETUS+UK treatment group was 66.7%, which is obviously higher than which in single UK group (20.0%, P=0.025), normal saline group (8.3%, P=0.005), and ETUS+ normal saline group (8.3%, P=0.005). The vascular recanalization rates in groups with different energy of ultrasound increased obviously as the radiated durations increased (P=0.006, 0.001), while no apparent effect of energy of ultrasound on the vascular recanalization rate was found in the groups with different radiated duration (Pgt;0.05). The eyes which had undergone ETUS treatment had retinal tissue damage and ultrastructure changes of the retinal ganglion cells (RGC), and deteriorated as the radiated duration increased. Conclusion ETUS may enhance the thrombolysis induced by urokinase in experimental retinal vein occlusion. Simultaneously, ETUS can lead to the damage of retinal tissue and changes of the ultrastructure of RGC. (Chin J Ocul Fundus Dis, 2007, 23: 166-169)
Objective To explore the association of pretreatment prognostic nutritional index (PNI) with the prognosis of small cell lung cancer (SCLC) patients. Methods The PubMed, Web of Science, Embase, China National Knowledge Infrastructure, WanFang and VIP databases were searched for relevant literature which identified the prognostic role of PNI in SCLC up to March 9th, 2022. The primary endpoint was overall survival (OS) and the secondary endpoint was progression-free survival (PFS). The hazard ratio (HR) and 95% confidence interval (CI) were combined by Stata 12.0 software. Results A total of 19 retrospective cohort studies were included, involving 5999 participates. The pooled results indicated that low pretreatment PNI predicted poorer OS [HR=1.58, 95%CI (1.37, 1.83), P<0.001] and PFS [HR=1.51, 95%CI (1.03, 2.22), P=0.037]. Conclusion Low pretreatment PNI may be a risk factor for poor prognosis of SCLC patients and could be applied for the evaluation of prognosis and formulation of therapy strategy.
Temporomandibular joint disorder (TMD) is a general term for a group of diseases. Clinically, it often presents as pain in the temporomandibular joint and surrounding muscles and soft tissues, often involving the temporomandibular joint, chewing muscles, and anterior joint area. There are also abnormalities in jaw movement, function, joint sounds, crushing sounds, and murmurs. This article provides a review of the epidemiology, etiology, clinical characteristics, auxiliary examinations, rehabilitation assessment, and rehabilitation treatment of TMD, in order to improve understanding of TMD rehabilitation assessment and provide reference for clinical rehabilitation treatment of TMD.
Objective To investigate the operative techniques and cl inical results of sural neurocutaneous vascular flap pedicled on the relatively higher and main perforating branch of peroneal artery in repairing small and medium-sized soft tissue defects in ankle. Methods From July 2004 to February 2007, 14 patients (9 males and 5 females, aged 19-53 years) withsmall and medium-sized soft tissue defects in ankle were treated, including 4 cases of skin necrosis caused by surgery for achilles tendon rupture, 3 soft tissue defects due to car accident, 2 crush injury due to fall ing heavy objects, 2 chronical infectious ulcer, 2 skin necrosis cuased by surgery for calcaneus fracture and 1 melanoma resection in heel. Ranging from 4 cm × 2 cm to 9 cm × 5 cm and combing with exposure of either tendon or bone, the defects were in ankle areas (12 cases) and weight-bearing heel (2 cases). The time from injury to hospital ization was 12 days to 13 months, except 3 cases of emergency hospital ization. After thorough debridement, the sural neurocutaneous vascular flaps (13 cm × 5 cm - 36 cm × 6 cm ) pedicled on the perforating branch of peroneal artery was harvested to repair the defects. The donor sites were sutured directly. Results Postoperatively all the flaps survived, and all the donor sites and wounds healed by first intention. Over a 7-23 month follow-up period, the texture, appearance and color of the flaps in all cases were good, with two-point discrimination of 7-12 mm.The function of ankle obtained satisfactory recovery with normal in-shoe gait. Conclusion With a rel iable blood supply, simple operative procedure, sound repair of wound and satisfactory recovery of l imb function, the sural neurocutaneous vascular flap pedicled on the relatively higher and main perforating branch of peroneal artery is appl icable for the repair of small and medium-sized defects in the ankle and weight-bearing area of heel, especially for patients who have no satisfactory perforating branch in lower position.
ObjectiveTo explore the clinical effect of kinesio-taping therapy on hemifacial spasm.MethodsPatients with hemifacial spasm in the Rehabilitation Medical Center of West China Hospital, Sichuan University from June 2015 to December 2018 were included. They were randomly divided into the kinesio-taping group and control group. The patients in the control group underwent ultrashort wave therapy and facial muscle function training: once a day, 10 days as a course of treatment; 2 days rest between each course; a total of 3 courses of treatment. In the kinesio-taping group, besides the original treatment, the kinesio-taping therapy was added: once a day, 10 times as a course of treatment; 2 days rest between each course; a total of 3 courses of treatment. The clinical effect of the two groups was observed.ResultsA total of 60 patients were included, with 30 in each of the two groups. There was no significant difference in the classification of facial muscle spasm between the two groups before the treatment (Z=−0.233, P=0.816). After the treatment, the difference in the classification of facial muscle spasm between the two groups was statistically significant (Z=−3.062, P=0.002); while both the kinesio-taping group (Z=−4.688, P< 0.001) and the control group (Z=−3.804, P< 0.001) improved compared with those before the treatment. The effect of kinesio-taping group [93.33% (28/30)] was better than that of the control group [76.67% (23/30)] (Z=−3.073, P=0.002).ConclusionKinesio-taping therapy can relieve the stiffness and pain caused by facial spasm, promote the recovery of facial muscle sensory function and bilateral coordinated movement, and relieve the clinical symptoms of patients,with the advantages of simple operation and good effect.