This study reported a case of intrahepatic splenosis with CT and MR findings mimicking hepatocellular carcinoma. The patient had two risk factors for hepatocellular carcinoma, including elevated alpha-fetoprotein and a history of hepatitis B virus infection, and had previously splenectomy due to spleen trauma. This paper briefly described the etiology and pathogenesis of intrahepatic splenosis and reviewed the radiological findings of this disease reported in previous literature, in order to strengthen readers’ understanding of intrahepatic splenosis and reduce the misdiagnosis rate.