Research progress of circRNA in retinoblastoma_Chinese Journal of Ocular Fundus Diseases

Authors：

Wei Pengxue ^1,2 , Liang Jia ² , Wang Shijing ² , Fang Dong ² ,  Zhang Shaochong ^1,2

1. The Second Clinical Medical College, Jinan University, Guangdong Shenzhen 518020, China;
2. Shenzhen Eye Hospital of Jinan University, Shenzhen Institute of Eye Disease Control, Guangdong Shenzhen 518040, China;

Corresponding author：

Zhang Shaochong, Email: zhangshaochong@gzzoc.com

Keywords：

Retinoblastoma; CircRNA; Cancer biomarker; Molecular targeting treatment; Review

DOI：

10.3760/cma.j.cn511434-20231120-00465

Video：

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Abstract Full text Figures/Tables Video References Cited by

Retinoblastoma (RB), the most common primary intraocular malignancy in infants and young children, poses a serious threat to visual function and the life of children when systemic metastasis occurs. Circular RNA (circRNA) is a recently discovered class of non-coding RNA that mainly functions as competitive endogenous RNA by regulating gene expression through competing with microRNA. circRNA can function as oncogenes or tumor suppressors, regulating various biological processes in RB cells, such as proliferation, migration, apoptosis, autophagy, and drug resistance, thereby providing new therapeutic targets for RB. In addition, the differential expression of circRNA in tumor tissues or exosomes is expected to be a potential biomarker for RB. Further studies and explorations are still needed for the functions and regulatory mechanisms of circRNA in RB to reveal their precise roles in organisms and potential clinical applications.

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1. Stacey AW, Bowman R, Foster A, et al. Incidence of retinoblastoma has increased: results from 40 European countries[J]. Ophthalmology, 2021, 128(9): 1369-1371. DOI: 10.1016/j.ophtha.2021.01.024.
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3. Singh G, Daniels AB. Disparities in retinoblastoma presentation, treatment, and outcomes in developed and less-developed countries[J]. Semin Ophthalmol, 2016, 31(4): 310-316. DOI: 10.3109/08820538.2016.1154177.
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5. Zhang L, Wu J, Li YJ, et al. Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis[J]. Cancer Cell Int, 2020, 20: 301. DOI: 10.1186/s12935-020-01396-4.
6. Xu L, Long H, Zhou B, et al. CircMKLN1 suppresses the progression of human retinoblastoma by modulation of miR-425-5p/PDCD4 axis[J]. Curr Eye Res, 2021, 46(11): 1751-1761. DOI: 10.1080/02713683.2021.1927110.
7. Qu S, Yang X, Li X, et al. Circular RNA: a new star of noncoding RNAs[J]. Cancer Lett, 2015, 365(2): 141-148. DOI: 10.1016/j.canlet.2015.06.003.
8. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015, 22(3): 256-264. DOI: 10.1038/nsmb.2959.
9. Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency[J]. Nature, 2013, 495(7441): 333-338. DOI: 10.1038/nature11928.
10. Li Q, Zhao YH, Xu C, et al. Chemotherapy-induced senescence reprogramming promotes nasopharyngeal carcinoma metastasis by circRNA-mediated PKR activation[J/OL]. Adv Sci (Weinh), 2023, 10(8): e2205668[2023-01-22]. https://pubmed.ncbi.nlm.nih.gov/36683218/. DOI: 10.1002/advs.202205668.
11. Chen N, Zhao G, Yan X, et al. A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1[J]. Genome Biol, 2018, 19(1): 218. DOI: 10.1186/s13059-018-1594-y.
12. Li K, Peng ZY, Wang R, et al. Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7[J]. Mol Cancer, 2023, 22(1): 103. DOI: 10.1186/s12943-023-01811-0.
13. Li S, Weng J, Song F, et al. Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression[J]. Cell Death Dis, 2020, 11(6): 452. DOI: 10.1038/s41419-020-2616-8.
14. Zhang HD, Jiang LH, Hou JC, et al. Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer[J]. Biomed Pharmacother, 2018, 107: 1342-1353. DOI: 10.1016/j.biopha.2018.08.030.
15. Chen NN, Chao DL, Li XG. Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis[J]. Cell Biochem Funct, 2020, 38(8): 1036-1046. DOI: 10.1002/cbf.3535.
16. Zuo X, Fu C, Xie J, et al. Hsa_circ_0000527 downregulation suppresses the development of retinoblastoma by modulating the miR-27a-3p/HDAC9 pathway[J]. Curr Eye Res, 2022, 47(1): 115-126. DOI: 10.1080/02713683.2021.1925697.
17. Liang T, Fan M, Meng Z, et al. Circ_0000527 drives retinoblastoma progression by regulating miR-1236-3p/SMAD2 pathway[J]. Curr Eye Res, 2022, 47(4): 624-633. DOI: 10.1080/02713683.2021.2007535.
18. Yu B, Zhao J, Dong Y. Circ_0000527 promotes retinoblastoma progression through modulating miR-98-5p/XIAP pathway[J]. Curr Eye Res, 2021, 46(9): 1414-1423. DOI: 10.1080/02713683.2021.1891255.
19. Zheng T, Chen W, Wang X, et al. Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis[J/OL]. Exp Eye Res, 2021, 211: 108650[2021-06-05]. https://pubmed.ncbi.nlm.nih.gov/34102206/. DOI: 10.1016/j.exer.2021.108650.
20. Sun Z, Zhang A, Hou M, et al. Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p[J]. Bioengineered, 2020, 11(1): 949-957. DOI: 10.1080/21655979.2020.1814670.
21. Wang HJ, Li MZ, Cui HB, et al. CircDHDDS/miR-361-3p/WNT3A axis promotes the development of retinoblastoma by regulating proliferation, cell cycle, migration, and invasion of retinoblastoma cells[J]. Neurochem Res, 2020, 45(11): 2691-2702. DOI: 10.1007/s11064-020-03112-0.
22. Jiang YH, Xiao F, Wang L, et al. Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis[J]. Mol Cell Biochem, 2021, 476(1): 69-80. DOI: 10.1007/s11010-020-03886-5.
23. Liu H, Yuan HF, Xu D, et al. Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p[J]. Eur Rev Med Pharmacol Sci, 2020, 24(23): 12080-12092. DOI: 10.26355/eurrev_ 202012_23997.
24. Zhao W, Wang S, Qin T, et al. Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3[J]. J Cell Biochem, 2020, 121(7): 3516-3525. DOI: 10.1002/jcb.29631.
25. Huang YL, Xue BG, Pan JH, et al. Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblasto ma by regulating ROCK1 expression[J/OL]. Exp Mol Pathol, 120: 104637[2021-04-18]. https://pubmed.ncbi.nlm.nih.gov/33844975/. DOI: 10.1016/j.yexmp.2021.104637.
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