Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury_Journal of Biomedical Engineering

Authors：

DU Xincheng ¹ , WANG Jibo ² , ZHAO Wen ² , CHEN Pu ² ,  OU Gaozhi ¹

1. School of Physical Education, China University of Geosciences, Wuhan 430074, P.R.China;
2. Department of Biomedical Engineering, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan 430071, P.R.China;

Corresponding author：

Keywords：

sport-related traumatic brain injury; tissue engineering; sports medicine; human relevant in vitro organotypic models; brain organoid; brain-on-a-chip

DOI：

10.7507/1001-5515.202012050

Video：

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Sports-related traumatic brain injury (srTBI) is a traumatic brain injury (TBI) caused by sports, which can result in cognitive and motor dysfunction. Currently, research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models. However, many differences exist in cell populations and inflammatory responses between these models and human pathophysiological processes. Most of the researches derived from the models can’t effectively conducted translational research. Emerging three-dimensional (3D) in vitro models bridge the limitations of traditional models in simulating the pathophysiological processes of human srTBI and provide new means to understand srTBI. A literature has reported the research progress of emerging 3D in vitro models in neurological diseases, but there is a lack of systematic summary of the mentioned models in srTBI studies. Here, we review the research progress of emerging 3D in vitro models of srTBI, discuss the advantages and limitations of existing models, and further prospect the future trend of srTBI models. This paper aims to provide a new research perspective for researchers in tissue engineering and sports medicine to study the molecular mechanisms of srTBI and develop neuroprotective drugs.

Citation： DU Xincheng, WANG Jibo, ZHAO Wen, CHEN Pu, OU Gaozhi. Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury. Journal of Biomedical Engineering, 2021, 38(4): 797-804. doi: 10.7507/1001-5515.202012050 Copy

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1. Baldwin G T, Breiding M J, Comstock R D. Epidemiology of sports concussion in the United States. Handb Clin Neurol, 2018, 158: 63-74.
2. Register-Mihalik J K, Kay M C. The current state of sports concussion. Neurol Clin, 2017, 35(3): 387-402.
3. Theadom A, Mahon S, Hume P, et al. Incidence of sports-related traumatic brain injury of all severities: a systematic review. Neuroepidemiology, 2020, 54(2): 192-199.
4. Satarasinghe P, Hamilton D K, Buchanan R J, et al. Unifying pathophysiological explanations for sports-related concussion and concussion protocol management: literature review. J Exp Neurosci, 2019, 13: 1179069518824125.
5. Begum G, Reddy R, Yakoub K M, et al. Differential expression of circulating inflammatory proteins following sport-related traumatic brain injury. Int J Mol Sci, 2020, 21(4): 1216.
6. Centers for Disease Control and Prevention. Facts about concussion and brain injury. (2018)[2021-04-30]. https://www.cdc.gov/traumaticbraininjury/pdf/Fact_Sheet_ConcussTBI-a.pdf.
7. 刘媛. 轻度脑创伤的研究进展. 中国临床神经科学, 2019, 27(2): 182-185, 215.
8. 邢聪, 吴瑛, 项贤林. 美国运动损伤前沿研究热点与内容分析—基于科学知识图谱的可视化研究. 体育科学, 2016, 36(9): 66-72.
9. Liaudanskaya V, Chung J Y, Mizzoni C, et al. Modeling controlled cortical impact injury in 3D brain-like tissue cultures. Adv Healthc Mater, 2020, 9(12): e2000122.
10. Sagarkar S, Balasubramanian N, Mishra S, et al. Repeated mild traumatic brain injury causes persistent changes in histone deacetylase function in hippocampus: implications in learning and memory deficits in rats. Brain Res, 2019, 1711: 183-192.
11. Zhao Y, Demirci U, Chen Y, et al. Multiscale brain research on a microfluidic chip. Lab on a Chip, 2020, 20(9): 1531-1543.
12. Chen C, Dong X, Fang K H, et al. Develop a 3D neurological disease model of human cortical glutamatergic neurons using micropillar-based scaffolds. Acta Pharm Sin B, 2019, 9(3): 557-564.
13. Wang K, Le L, Chun B M, et al. A novel osteogenic cell line that differentiates into GFP-tagged osteocytes and forms mineral with a bone-like lacunocanalicular structure. J Bone Miner Res, 2019, 34(6): 979-995.
14. Scimone M T, Cramer III H C, Hopkins P, et al. Application of mild hypothermia successfully mitigates neural injury in a 3D in-vitro model of traumatic brain injury. PLoS One, 2020, 15(4): e0229520.
15. Tang-Schomer M D, White J D, Tien L W, et al. Bioengineered functional brain-like cortical tissue. Proceedings of the National Academy of Sciences, 2014, 111(38): 13811-13816.
16. Yap Y C, Dickson T C, King A E, et al. Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury. Biomicrofluidics, 2014, 8(4): 044110.
17. Fournier A J, Rajbhandari L, Shrestha S, et al. In vitro and in situ visualization of cytoskeletal deformation under load: traumatic axonal injury. FASEB J, 2014, 28(12): 5277-5287.
18. Fehily B, Fitzgerald M. Repeated mild traumatic brain injury: potential mechanisms of damage. Cell Transplant, 2017, 26(7): 1131-1155.
19. Yap Y C, King A E, Guijt R M, et al. Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse. PLoS One, 2017, 12(5): e0176997.
20. Shi W, Dong P, Kuss M A, et al. Design and evaluation of an in vitro mild traumatic brain injury modeling system using 3D printed mini impact device on the 3D cultured human iPSC derived neural progenitor cells. Advanced Healthcare Materials, 2021: 2100180.
21. Lancaster M A, Renner M, Martin C A, et al. Cerebral organoids model human brain development and microcephaly. Nature, 2013, 501(7467): 373-379.
22. Qian X, Song H, Ming G L. Brain organoids: advances, applications and challenges. Development, 2019, 146(8): dev166074.
23. Cherskov A, Sestan N. A screen of brain organoids to study neurodevelopmental disease. Nature, 2021, 589(7840): 24-25.
24. Wulansari N, Darsono W H W, Woo H J, et al. Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations. Sci Adv, 2021, 7(8): eabb1540.
25. Park J C, Jang S Y, Lee D, et al. A logical network-based drug-screening platform for Alzheimer's disease representing pathological features of human brain organoids. Nat Commun, 2021, 12(1): 280.
26. Qiao H, Guo M, Shang J, et al. Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes. PLoS Pathog, 2020, 16(10): e1008899.
27. Lai J D, Berlind J E, Fricklas G, et al. A model of traumatic brain injury using human iPSC-derived cortical brain organoids. bioRxiv, 2020: 180299.
28. Qiao H, Zhang Y S, Chen P. Commentary: human brain organoid-on-a-chip to model prenatal nicotine exposure. Front Bioeng Biotechnol, 2018, 6: 138.
29. Wang Y, Wang L, Zhu Y, et al. Human brain organoid-on-a-chip to model prenatal nicotine exposure. Lab on a Chip, 2018, 18(6): 851-860.
30. Wang Z, He X, Qiao H, et al. Global trends of organoid and organ-on-a-chip in the past decade: a bibliometric and comparative study. Tissue Eng Part A, 2020, 26(11-12): 656-671.
31. Ren T, Chen P, Gu L, et al. Soft ring-shaped cellu-robots with simultaneous locomotion in batches. Adv Mater, 2020, 32(8): e1905713.
32. Pham M T, Pollock K M, Rose M D, et al. Generation of human vascularized brain organoids. Neuroreport, 2018, 29(7): 588-593.
33. Xie R, Zheng W, Guan L, et al. Engineering of hydrogel materials with perfusable microchannels for building vascularized tissues. Small, 2020, 16(15): e1902838.
34. Santra T S. Microfluidics and bio-MEMS: devices and applications. CRC Press, 2020.

Journal of Biomedical Engineering

Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury

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