Progress in antibacterial coatings of titanium implants surfaces_Journal of Biomedical Engineering

Authors：

HE Xuhong ¹ , GUO Chaiqiong ¹ , LIU Xuanyu ¹ , WANG Yuhui ¹ , LIANG Ziwei ^1,2 , LIAN Xiaojie ^1,2 , HU Yinchun ^1,2 ,  HUANG Di ^1,2 ,  WEI Yan ^1,2

1. Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Research Center for Nanobiomaterials and Regenerative Medicine, Taiyuan 030024, P. R. China;
2. Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China;

Corresponding author：

Keywords：

Titanium implants; Biocompatibility; Antibacterial ability; Metal ion antibacterial

DOI：

10.7507/1001-5515.202209051

Video：

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In recent years, bone implant materials such as titanium and titanium alloys have been widely used in the biomedical field due to their excellent mechanical properties and good biocompatibility. However, in clinical practice, bacterial adhesion to the material surface and postoperative infection issues may lead to implantation failure. Based on the antibacterial mechanism, this review elaborated on the antibacterial surface design of titanium implants from the aspects of anti-bacterial adhesion, contact sterilization and photocontrol sterilization. Surface modification of titanium or titanium-based alloy implants with different techniques can inhibit bacteria and promote osseointegration. Thus, the application range of multifunctional titanium-based implants in the field of orthopedics will be expanded.

Citation： HE Xuhong, GUO Chaiqiong, LIU Xuanyu, WANG Yuhui, LIANG Ziwei, LIAN Xiaojie, HU Yinchun, HUANG Di, WEI Yan. Progress in antibacterial coatings of titanium implants surfaces. Journal of Biomedical Engineering, 2024, 41(1): 191-198. doi: 10.7507/1001-5515.202209051 Copy

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2.	Pantović Pavlović M R, Stanojevic B P, Pavlovic M M, et al. Anodizing/anaphoretic electrodeposition of nano-calcium phosphate/chitosan lactate multifunctional coatings on titanium with advanced corrosion resistance, bioactivity, and antibacterial properties. ACS Biomater Sci Eng, 2021, 7(7): 3088-3102.
3.	Minkiewicz-Zochniak A, Jarzynka S, Iwańska A, et al. Biofilm formation on dental implant biomaterials by Staphylococcus aureus strains isolated from patients with cystic fibrosis. Materials, 2021, 14(8): 2030-2045.
4.	Amin Yavari S, Castenmiller S M, van Strijp J A G, et al. Combating implant infections: shifting focus from bacteria to host. Adv Mater, 2020, 32(43): 2002962-2002987.
5.	Ray S S, Dangayach R, Kwon Y N. Surface engineering for anti-wetting and antibacterial membrane for enhanced and fouling resistant membrane distillation performance. Chem Eng J, 2021, 405: 126702-126719.
6.	Visan A, Cristescu R, Stefan N, et al. Antimicrobial polycaprolactone/polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering. Appl Surf Sci, 2017, 417: 234-243.
7.	刘娣, 宫月娇, 肖群, 等. 钛表面接枝聚乙二醇-精氨酸-甘氨酸-天冬氨酸聚合物分子刷对细菌和成骨细胞黏附的影响. 中华口腔医学杂志, 2016, 51(8): 491-495.
8.	袁璋. 钛基植入体促成骨及抗菌表面改性研究. 重庆: 重庆大学, 2020.
9.	He X, Zhang J, Xie L, et al. Phytic acid-promoted rapid fabrication of natural polypeptide coatings for multifunctional applications. Chem Eng J, 2022, 440: 135917-135927.
10.	马朝阳, 方文良, 肖群, 等. 载银多聚赖氨酸-海藻酸钠静电自组装多层膜修饰钛表面及其抗菌研究. 口腔材料器械杂志, 2017, 26(2): 67-73.
11.	孙玉洁, 章露娇, 赵玉清, 等, 基于表面引发聚合构建表面抗菌功能化牙科植入体. 表面技术, 2019, 48(7): 237-246, 255 . .
12.	Teixeira G T L, Gelamo R V, Mateus Santos Obata M, et al. Exploring the functionalization of Ti-6Al-4V alloy with the novel antimicrobial peptide JIChis-2 via plasma polymerization. Biofouling, 2023, 39(1): 47-63.
13.	Chua P H, Neoh K G, Kang E T, et al. Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion. Biomaterials, 2008, 29(10): 1412-1421.
14.	张广瑞. 壳聚糖季铵盐和PAA/PAH涂层镍钛合金的制备与细胞相容性研究. 兰州: 兰州大学, 2020.
15.	Durdu S, Arslanturk A, Aktug S L, et al. A comparison study on bioactivity and antibacterial properties of Ag-, Cu-and Zn-deposited oxide coatings produced on titanium. J Mater Sci, 2022, 57: 17203-17218.
16.	李娇娇, 韦章澳, 张维波, 等. 钛表面载银的硫酸乙酰肝素/壳聚糖抗菌涂层的构建. 安徽医科大学学报, 2022, 57(5): 754-758.
17.	Chen X, Cai K, Fang J, et al. Dual action antibacterial TiO₂ nanotubes incorporated with silver nanoparticles and coated with a quaternary ammonium salt (QAS). Surf Coat Technol, 2013, 216: 158-165.
18.	Zuo K, Wang L, Wang Z, et al. Zinc-doping induces evolution of biocompatible strontium–calcium-phosphate conversion coating on titanium to improve antibacterial property. ACS Appl Mater Interfaces, 2022, 14(6): 7690-7705.
19.	Hu Y, Zhou H, Liu T, et al. Construction of mussel-inspired dopamine-Zn²⁺ coating on titanium oxide nanotubes to improve hemocompatibility, cytocompatibility, and antibacterial activity. Front Bioeng Biotech, 2022, 10: 884258.
20.	Li B, Yang T, Sun R, et al. Biological and antibacterial properties of composite coatings on titanium surfaces modified by microarc oxidation and sol-gel processing. Dent Mater J, 2021, 40(2): 455-463.
21.	Liang S, Jian L, Wang D, et al. Enhancement of antibacterial and cytocompatibility of Ti by Zn-doped BST coatings. Mater Lett, 2023, 338: 134018-134022.
22.	李兴平. 钛表面载铜抗菌功能膜制备及性能研究. 泸州: 西南医科大学, 2020.
23.	Liu S, Zhang Z, Zhang J, et al. Construction of a TiO₂/Cu₂O multifunctional coating on Ti-Cu alloy and its influence on the cell compatibility and antibacterial properties. Surf Coat Technol, 2021, 421: 127438-127453.
24.	Fang J, Wan Y, Sun Y, et al. Near-infrared-activated nanohybrid coating with black phosphorus/zinc oxide for efficient biofilm eradication against implant-associated infections. Chem Eng J, 2022, 435: 134935-134949.
25.	Akhavan O, Azimirad R, Safa S, et al. Visible light photo-induced antibacterial activity of CNT–doped TiO₂ thin films with various CNT contents. J Mater Chem, 2010, 20(35): 7386-7392.
26.	Ueda T, Ueda K, Ito K, et al. Visible-light-responsive antibacterial activity of Au-incorporated TiO₂ layers formed on Ti–(0–10) at% Au alloys by air oxidation. J Biomed Mater Res A, 2019, 107(5): 991-1000.
27.	Zeng J, Wang Y, Sun Z, et al. A novel biocompatible PDA/IR820/DAP coating for antibiotic/photodynamic/photothermal triple therapy to inhibit and eliminate Staphylococcus aureus biofilm. Chem Eng J, 2020, 394: 125017-125030.
28.	Yuan Z, Tao B, He Y, et al. Biocompatible MoS₂/PDA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation. Biomaterials, 2019, 217: 119290-119307.
29.	Xu K, Zhou M, Chen W, et al. Bioinspired polydopamine/graphene oxide/collagen nanofilms as a controlled release carrier of bioactive substances. Chem Eng J, 2021, 405: 126930-126945.
30.	He F, Li J, Wang Y, et al. Design of cefotaxime sodium-loaded polydopamine coatings with controlled surface roughness for titanium implants. ACS Biomater Sci Eng, 2022, 8(11): 4751-4763.
31.	Yuan Z, Wu J, Fu Z, et al. Polydopamine-mediated interfacial functionalization of implants for accelerating infected bone repair through light‐activatable antibiosis and carbon monoxide gas regulated macrophage polarization. Adv Funct Mater, 2022, 32(27): 2200374-2200389.
32.	Yan H, Zhang B, Zhang Y, et al. Fluorescent carbon dot–curcumin nanocomposites for remarkable antibacterial activity with synergistic photodynamic and photothermal abilities. ACS Appl Bio Mater, 2021, 4(9): 6703-6718.
33.	Dai D, Zhou D, He L, et al. Graphene oxide nanocoating for enhanced corrosion resistance, wear resistance and antibacterial activity of nickel-titanium shape memory alloy. Surf Coat Technol, 2022, 431: 128012-128025.
34.	Qin W, Ma J, Liang Q, et al. Tribological, cytotoxicity and antibacterial properties of graphene oxide/carbon fibers/polyetheretherketone composite coatings on Ti–6Al–4V alloy as orthopedic/dental implants. J Mech Behav of Biomed, 2021, 122: 104659-104667.
35.	Chai M Z, An M W, Zhang X Y, et al. In vitro and in vivo antibacterial activity of graphene oxide-modified porous TiO₂ coatings under 808-nm light irradiation. Rare Met, 2022, 41(2): 540-545.
36.	Eshghinejad P, Farnoush H, Bahrami M S, et al. Electrophoretic deposition of bioglass/graphene oxide composite on Ti-alloy implants for improved antibacterial and cytocompatible properties. Mater Technol, 2020, 35(2): 69-74.
37.	Huo J, Jia Q, Wang K, et al. Metal-phenolic networks assembled on TiO₂ nanospikes for antimicrobial peptide deposition and osteoconductivity enhancement in orthopedic applications. Langmuir, 2023, 39(3): 1238-1249.

1. 范竞一, 马迅, 李伟, 等. 医用钛合金表面改性技术研究进展. 功能材料, 2022, 53(7): 7027-7039.
2. Pantović Pavlović M R, Stanojevic B P, Pavlovic M M, et al. Anodizing/anaphoretic electrodeposition of nano-calcium phosphate/chitosan lactate multifunctional coatings on titanium with advanced corrosion resistance, bioactivity, and antibacterial properties. ACS Biomater Sci Eng, 2021, 7(7): 3088-3102.
3. Minkiewicz-Zochniak A, Jarzynka S, Iwańska A, et al. Biofilm formation on dental implant biomaterials by Staphylococcus aureus strains isolated from patients with cystic fibrosis. Materials, 2021, 14(8): 2030-2045.
4. Amin Yavari S, Castenmiller S M, van Strijp J A G, et al. Combating implant infections: shifting focus from bacteria to host. Adv Mater, 2020, 32(43): 2002962-2002987.
5. Ray S S, Dangayach R, Kwon Y N. Surface engineering for anti-wetting and antibacterial membrane for enhanced and fouling resistant membrane distillation performance. Chem Eng J, 2021, 405: 126702-126719.
6. Visan A, Cristescu R, Stefan N, et al. Antimicrobial polycaprolactone/polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering. Appl Surf Sci, 2017, 417: 234-243.
7. 刘娣, 宫月娇, 肖群, 等. 钛表面接枝聚乙二醇-精氨酸-甘氨酸-天冬氨酸聚合物分子刷对细菌和成骨细胞黏附的影响. 中华口腔医学杂志, 2016, 51(8): 491-495.
8. 袁璋. 钛基植入体促成骨及抗菌表面改性研究. 重庆: 重庆大学, 2020.
9. He X, Zhang J, Xie L, et al. Phytic acid-promoted rapid fabrication of natural polypeptide coatings for multifunctional applications. Chem Eng J, 2022, 440: 135917-135927.
10. 马朝阳, 方文良, 肖群, 等. 载银多聚赖氨酸-海藻酸钠静电自组装多层膜修饰钛表面及其抗菌研究. 口腔材料器械杂志, 2017, 26(2): 67-73.
11. 孙玉洁, 章露娇, 赵玉清, 等, 基于表面引发聚合构建表面抗菌功能化牙科植入体. 表面技术, 2019, 48(7): 237-246, 255 . .
12. Teixeira G T L, Gelamo R V, Mateus Santos Obata M, et al. Exploring the functionalization of Ti-6Al-4V alloy with the novel antimicrobial peptide JIChis-2 via plasma polymerization. Biofouling, 2023, 39(1): 47-63.
13. Chua P H, Neoh K G, Kang E T, et al. Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion. Biomaterials, 2008, 29(10): 1412-1421.
14. 张广瑞. 壳聚糖季铵盐和PAA/PAH涂层镍钛合金的制备与细胞相容性研究. 兰州: 兰州大学, 2020.
15. Durdu S, Arslanturk A, Aktug S L, et al. A comparison study on bioactivity and antibacterial properties of Ag-, Cu-and Zn-deposited oxide coatings produced on titanium. J Mater Sci, 2022, 57: 17203-17218.
16. 李娇娇, 韦章澳, 张维波, 等. 钛表面载银的硫酸乙酰肝素/壳聚糖抗菌涂层的构建. 安徽医科大学学报, 2022, 57(5): 754-758.
17. Chen X, Cai K, Fang J, et al. Dual action antibacterial TiO₂ nanotubes incorporated with silver nanoparticles and coated with a quaternary ammonium salt (QAS). Surf Coat Technol, 2013, 216: 158-165.
18. Zuo K, Wang L, Wang Z, et al. Zinc-doping induces evolution of biocompatible strontium–calcium-phosphate conversion coating on titanium to improve antibacterial property. ACS Appl Mater Interfaces, 2022, 14(6): 7690-7705.
19. Hu Y, Zhou H, Liu T, et al. Construction of mussel-inspired dopamine-Zn²⁺ coating on titanium oxide nanotubes to improve hemocompatibility, cytocompatibility, and antibacterial activity. Front Bioeng Biotech, 2022, 10: 884258.
20. Li B, Yang T, Sun R, et al. Biological and antibacterial properties of composite coatings on titanium surfaces modified by microarc oxidation and sol-gel processing. Dent Mater J, 2021, 40(2): 455-463.
21. Liang S, Jian L, Wang D, et al. Enhancement of antibacterial and cytocompatibility of Ti by Zn-doped BST coatings. Mater Lett, 2023, 338: 134018-134022.
22. 李兴平. 钛表面载铜抗菌功能膜制备及性能研究. 泸州: 西南医科大学, 2020.
23. Liu S, Zhang Z, Zhang J, et al. Construction of a TiO₂/Cu₂O multifunctional coating on Ti-Cu alloy and its influence on the cell compatibility and antibacterial properties. Surf Coat Technol, 2021, 421: 127438-127453.
24. Fang J, Wan Y, Sun Y, et al. Near-infrared-activated nanohybrid coating with black phosphorus/zinc oxide for efficient biofilm eradication against implant-associated infections. Chem Eng J, 2022, 435: 134935-134949.
25. Akhavan O, Azimirad R, Safa S, et al. Visible light photo-induced antibacterial activity of CNT–doped TiO₂ thin films with various CNT contents. J Mater Chem, 2010, 20(35): 7386-7392.
26. Ueda T, Ueda K, Ito K, et al. Visible-light-responsive antibacterial activity of Au-incorporated TiO₂ layers formed on Ti–(0–10) at% Au alloys by air oxidation. J Biomed Mater Res A, 2019, 107(5): 991-1000.
27. Zeng J, Wang Y, Sun Z, et al. A novel biocompatible PDA/IR820/DAP coating for antibiotic/photodynamic/photothermal triple therapy to inhibit and eliminate Staphylococcus aureus biofilm. Chem Eng J, 2020, 394: 125017-125030.
28. Yuan Z, Tao B, He Y, et al. Biocompatible MoS₂/PDA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation. Biomaterials, 2019, 217: 119290-119307.
29. Xu K, Zhou M, Chen W, et al. Bioinspired polydopamine/graphene oxide/collagen nanofilms as a controlled release carrier of bioactive substances. Chem Eng J, 2021, 405: 126930-126945.
30. He F, Li J, Wang Y, et al. Design of cefotaxime sodium-loaded polydopamine coatings with controlled surface roughness for titanium implants. ACS Biomater Sci Eng, 2022, 8(11): 4751-4763.
31. Yuan Z, Wu J, Fu Z, et al. Polydopamine-mediated interfacial functionalization of implants for accelerating infected bone repair through light‐activatable antibiosis and carbon monoxide gas regulated macrophage polarization. Adv Funct Mater, 2022, 32(27): 2200374-2200389.
32. Yan H, Zhang B, Zhang Y, et al. Fluorescent carbon dot–curcumin nanocomposites for remarkable antibacterial activity with synergistic photodynamic and photothermal abilities. ACS Appl Bio Mater, 2021, 4(9): 6703-6718.
33. Dai D, Zhou D, He L, et al. Graphene oxide nanocoating for enhanced corrosion resistance, wear resistance and antibacterial activity of nickel-titanium shape memory alloy. Surf Coat Technol, 2022, 431: 128012-128025.
34. Qin W, Ma J, Liang Q, et al. Tribological, cytotoxicity and antibacterial properties of graphene oxide/carbon fibers/polyetheretherketone composite coatings on Ti–6Al–4V alloy as orthopedic/dental implants. J Mech Behav of Biomed, 2021, 122: 104659-104667.
35. Chai M Z, An M W, Zhang X Y, et al. In vitro and in vivo antibacterial activity of graphene oxide-modified porous TiO₂ coatings under 808-nm light irradiation. Rare Met, 2022, 41(2): 540-545.
36. Eshghinejad P, Farnoush H, Bahrami M S, et al. Electrophoretic deposition of bioglass/graphene oxide composite on Ti-alloy implants for improved antibacterial and cytocompatible properties. Mater Technol, 2020, 35(2): 69-74.
37. Huo J, Jia Q, Wang K, et al. Metal-phenolic networks assembled on TiO₂ nanospikes for antimicrobial peptide deposition and osteoconductivity enhancement in orthopedic applications. Langmuir, 2023, 39(3): 1238-1249.

Journal of Biomedical Engineering

Progress in antibacterial coatings of titanium implants surfaces

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