Research progress on the correlation between sarcopenia and osteoarthritis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

PENG Hongjun ,  ZENG Yi

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

ZENG Yi, Email: zengyigd@126.com

Keywords：

Sarcopenia; osteoarthritis; correlation; epidemiology; pathogenesis; clinical treatments; total joint arthroplasty

DOI：

10.7507/1002-1892.202209015

Video：

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Objective To review the research progress on the correlation between sarcopenia and osteoarthritis (OA). Methods The basic and clinical studies at home and abroad in recent years on sarcopenia and OA were extensively reviewed. The correlation between sarcopenia and OA was analyzed and summarized from five aspects: epidemiological status, risk factors, pathogenesis, clinical treatments, and the impact on joint arthroplasty. Results Sarcopenia and OA are common diseases in the elderly with high prevalence and can increase the ill risk of each other. They share a set of risk factors, and show negative interactive and influence on pathogenesis and clinical treatments, thus participating in each other’s disease process and reducing the treatment benefits. Clinical studies show that sarcopenia can affect the rehabilitation effect and increase the risk of postoperative complications after total joint arthroplasty in many ways. Conclusion Current research results show that sarcopenia and OA are related and can be mutually affected in the above 5 aspects, but more studies are needed to further clarify the relationship between them, so as to provide more theoretical basis for the understanding, prevention, diagnosis, and treatments of the two diseases.

Citation： PENG Hongjun, ZENG Yi. Research progress on the correlation between sarcopenia and osteoarthritis. Chinese Journal of Reparative and Reconstructive Surgery, 2022, 36(12): 1549-1557. doi: 10.7507/1002-1892.202209015 Copy

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2.	Petermann-Rocha F, Balntzi V, Gray SR, et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle, 2022, 13(1): 86-99.
3.	Tournadre A, Vial G, Capel F, et al. Sarcopenia. Joint Bone Spine, 2019, 86(3): 309-314.
4.	Vina ER, Kwoh CK. Epidemiology of osteoarthritis: literature update. Curr Opin Rheumatol, 2018, 30(2): 160-167.
5.	Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 2014, 15(2): 95-101.
6.	Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 2020, 21(3): 300-307.
7.	Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010, 39(4): 412-423.
8.	Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition:prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc, 2011, 12(4): 249-256.
9.	Studenski SA, Peters KW, Alley DE, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci, 2014, 69(5): 547-558.
10.	中华医学会骨科学分会关节外科学组, 中国医师协会骨科医师分会骨关节炎学组, 国家老年疾病临床医学研究中心 (湘雅医院), 等. 中国骨关节炎诊疗指南 (2021年版). 中华骨科杂志, 2021, 41(18): 1291-1314.
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16.	Dorhout BG, Overdevest E, Tieland M, et al. Sarcopenia and its relation to protein intake across older ethnic populations in the Netherlands: the HELIUS study. Ethn Health, 2022, 27(3): 705-720.
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21.	Liu X, Hou L, Zhao W, et al. The comparison of sarcopenia diagnostic criteria using AWGS 2019 with the other five criteria in west China. Gerontology, 2021, 67(4): 386-396.
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24.	Liu X, Hou L, Xia X, et al. Prevalence of sarcopenia in multi ethnics adults and the association with cognitive impairment: findings from West-China health and aging trend study. BMC Geriatr, 2020, 20(1): 63. doi: 10.1186/s12877-020-1468-5.
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53.	Silva JMS, Alabarse PVG, Teixeira VON, et al. Muscle wasting in osteoarthritis model induced by anterior cruciate ligament transection. PLoS One, 2018, 13(4): e0196682. doi: 10.1371/journal.pone.0196682.
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1. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
2. Petermann-Rocha F, Balntzi V, Gray SR, et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle, 2022, 13(1): 86-99.
3. Tournadre A, Vial G, Capel F, et al. Sarcopenia. Joint Bone Spine, 2019, 86(3): 309-314.
4. Vina ER, Kwoh CK. Epidemiology of osteoarthritis: literature update. Curr Opin Rheumatol, 2018, 30(2): 160-167.
5. Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 2014, 15(2): 95-101.
6. Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 2020, 21(3): 300-307.
7. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010, 39(4): 412-423.
8. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition:prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc, 2011, 12(4): 249-256.
9. Studenski SA, Peters KW, Alley DE, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci, 2014, 69(5): 547-558.
10. 中华医学会骨科学分会关节外科学组, 中国医师协会骨科医师分会骨关节炎学组, 国家老年疾病临床医学研究中心 (湘雅医院), 等. 中国骨关节炎诊疗指南 (2021年版). 中华骨科杂志, 2021, 41(18): 1291-1314.
11. Hida T, Harada A, Imagama S, et al. Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations. Aging Dis, 2014, 5(4): 226-237.
12. Zengin A, Kulkarni B, Khadilkar AV, et al. Prevalence of sarcopenia and relationships between muscle and bone in Indian men and women. Calcif Tissue Int, 2021, 109(4): 423-433.
13. Purcell SA, MacKenzie M, Barbosa-Silva TG, et al. Sarcopenia prevalence using different definitions in older community-dwelling canadians. J Nutr Health Aging, 2020, 24(7): 783-790.
14. Shafiee G, Keshtkar A, Soltani A, et al. Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies. J Diabetes Metab Disord, 2017, 16: 21. doi: 10.1186/s40200-017-0302-x.
15. Therakomen V, Petchlorlian A, Lakananurak N. Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study. Sci Rep, 2020, 10(1): 19551. doi: 10.1038/s41598-020-75250-y.
16. Dorhout BG, Overdevest E, Tieland M, et al. Sarcopenia and its relation to protein intake across older ethnic populations in the Netherlands: the HELIUS study. Ethn Health, 2022, 27(3): 705-720.
17. Xin C, Sun X, Lu L, et al. Prevalence of sarcopenia in older Chinese adults: a systematic review and meta-analysis. BMJ Open, 2021, 11(8): e041879. doi: 10.1136/bmjopen-2020-041879.
18. Wu X, Li X, Xu M, et al. Sarcopenia prevalence and associated factors among older Chinese population: Findings from the China Health and Retirement Longitudinal Study. PLoS One, 2021, 16(3): e0247617. doi: 10.1371/journal.pone.0247617.
19. Huang J, He F, Gu X, et al. Estimation of sarcopenia prevalence in individuals at different ages from Zheijang province in China. Aging (Albany NY), 2021, 13(4): 6066-6075.
20. 田小丽, 杨蕾, 沈静, 等. 乌鲁木齐市米东区社区中老年肌肉减少症患病率及影响因素. 中华骨质疏松和骨矿盐疾病杂志, 2020, 13(1): 21-26.
21. Liu X, Hou L, Zhao W, et al. The comparison of sarcopenia diagnostic criteria using AWGS 2019 with the other five criteria in west China. Gerontology, 2021, 67(4): 386-396.
22. Chen Z, Li WY, Ho M, et al. The prevalence of sarcopenia in Chinese older adults: Meta-analysis and meta-regression. Nutrients, 2021, 13(5): 1441. doi: 10.3390/nu13051441.
23. Pacifico J, Geerlings MAJ, Reijnierse EM, et al. Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis. Exp Gerontol, 2020, 131: 110801. doi: 10.1016/j.exger.2019.110801.
24. Liu X, Hou L, Xia X, et al. Prevalence of sarcopenia in multi ethnics adults and the association with cognitive impairment: findings from West-China health and aging trend study. BMC Geriatr, 2020, 20(1): 63. doi: 10.1186/s12877-020-1468-5.
25. Liu X, Hao Q, Hou L, et al. Ethnic groups differences in the prevalence of sarcopenia using the AWGS criteria. J Nutr Health Aging, 2020, 24(6): 665-671.
26. Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthritis Cartilage, 2022, 30(2): 184-195.
27. Driban JB, Harkey MS, Liu SH, et al. Osteoarthritis and aging: Young adults with osteoarthritis. Current Epidemiology Reports, 2020, 7(1): 9-15.
28. Safiri S, Kolahi AA, Smith E, et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017. Ann Rheum Dis, 2020, 79(6): 819-828.
29. Li D, Li S, Chen Q, et al. The prevalence of symptomatic knee osteoarthritis in relation to age, sex, area, region, and body mass index in China: A systematic review and meta-analysis. Front Med (Lausanne), 2020, 7: 304. doi: 10.3389/fmed.2020.00304.
30. Tang X, Wang S, Zhan S, et al. The prevalence of symptomatic knee osteoarthritis in china: results from the china health and retirement longitudinal study. Arthritis Rheumatol, 2016, 68(3): 648-653.
31. Callahan LF, Cleveland RJ, Allen KD, et al. Racial/ethnic, socioeconomic, and geographic disparities in the epidemiology of knee and hip osteoarthritis. Rheum Dis Clin North Am, 2021, 47(1): 1-20.
32. Jin WS, Choi EJ, Lee SY, et al. Relationships among obesity, sarcopenia, and osteoarthritis in the elderly. J Obes Metab Syndr, 2017, 26(1): 36-44.
33. Kim SR, Choi KH, Jung GU, et al. Associations between fat mass, lean mass, and knee osteoarthritis: The FIFTH Korean National Health and Nutrition Examination Survey (KNHANES V). Calcif Tissue Int, 2016, 99(6): 598-607.
34. Kemmler W, Teschler M, Goisser S, et al. Prevalence of sarcopenia in Germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FORMoSA study. Clin Interv Aging, 2015, 10: 1565-1573.
35. Dhannakulsakti P, Roopsawang I, Aree-Ue S. Sarcopenia among older adults with knee osteoarthritis: A cross-sectional study of prevalence and its associated factors. Pacific Rim International Journal of Nursing Research, 2022, 26(1): 121-134.
36. Martinez-Pena Y Valenzuela I, Akaaboune M. The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice. Mol Metab, 2020, 36: 100979. doi: 10.1016/j.molmet.2020.100979.
37. Wu H, Ballantyne CM. Skeletal muscle inflammation and insulin resistance in obesity. J Clin Invest, 2017, 127(1): 43-54.
38. Abete I, Konieczna J, Zulet MA, et al. Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial. J Cachexia Sarcopenia Muscle, 2019, 10(5): 974-984.
39. Nedunchezhiyan U, Varughese I, Sun AR, et al. Obesity, inflammation, and immune system in osteoarthritis. Front Immunol, 2022, 13: 907750. doi: 10.3389/fimmu.2022.907750.
40. Turner MC, Martin NRW, Player DJ, et al. Characterising hyperinsulinemia-induced insulin resistance in human skeletal muscle cells. J Mol Endocrinol, 2020, 64(3): 125-132.
41. Nishikawa H, Asai A, Fukunishi S, et al. Metabolic syndrome and sarcopenia. Nutrients, 2021, 13(10). doi: 10.3390/nu13103519.
42. Ribeiro M, López de Figueroa P, Blanco FJ, et al. Insulin decreases autophagy and leads to cartilage degradation. Osteoarthritis Cartilage, 2016, 24(4): 731-739.
43. Qiao L, Li Y, Sun S. Insulin exacerbates inflammation in fibroblast-like synoviocytes. Inflammation, 2020, 43(3): 916-936.
44. Zaharia OP, Pesta DH, Bobrov P, et al. Reduced muscle strength is associated with insulin resistance in type 2 diabetes patients with osteoarthritis. J Clin Endocrinol Metab, 2021, 106(4): 1062-1073.
45. Hernández-Luis R, Martín-Ponce E, Monereo-Muñoz M, et al. Prognostic value of physical function tests and muscle mass in elderly hospitalized patients. A prospective observational study. Geriatr Gerontol Int, 2018, 18(1): 57-64.
46. Veronese N, La Tegola L, Mattera M, et al. Vitamin D intake and magnetic resonance parameters for knee osteoarthritis: Data from the osteoarthritis initiative. Calcif Tissue Int, 2018, 103(5): 522-528.
47. Pan L, Xie W, Fu X, et al. Inflammation and sarcopenia: A focus on circulating inflammatory cytokines. Exp Gerontol, 2021, 154: 111544. doi: 10.1016/j.exger.2021.111544.
48. Baar MP, Perdiguero E, Muñoz-Cánoves P, et al. Musculoskeletal senescence: a moving target ready to be eliminated. Curr Opin Pharmacol, 2018, 40: 147-155.
49. Xu J, She G, Gui T, et al. Knee muscle atrophy is a risk factor for development of knee osteoarthritis in a rat model. J Orthop Translat, 2019, 22: 67-72.
50. Tanaka R, Hirohama K, Ozawa J. Can muscle weakness and disability influence the relationship between pain catastrophizing and pain worsening in patients with knee osteoarthritis? A cross-sectional study. Braz J Phys Ther, 2019, 23(3): 266-272.
51. Steidle-Kloc E, Rabe K, Eckstein F, et al. Is muscle strength in a painful limb affected by knee pain status of the contralateral limb? -Data from the Osteoarthritis Initiative. Ann Anat, 2019, 221: 68-75.
52. Noehren B, Kosmac K, Walton RG, et al. Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis. Osteoarthritis Cartilage, 2018, 26(10): 1359-1368.
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