Research progress of role of <i>Helicobacter pylori</i> on oncogenesis and progression of pancreatic cancer _CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CAO Chengliang , QU Fengzhi ,  WANG Gang , SUN Bei

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

WANG Gang, Email: wgilu79@163.com

Keywords：

Helicobacter pylori; pancreatic cancer; pathogenesis; chronic pancreatitis

DOI：

10.7507/1007-9424.201702019

Video：

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Objective To study effects of Helicobacter pylori on oncogenesis and progression of pancreatic cancer. Method The current literatures on the relationship between the Helicobacter pylori and the pancreatic cancer were collected and reviewed. Results The Helicobacter pylori infection might play a role in the development of the pancreatic cancer. The infection rate of the Helicobacter pylori in the patients with pancreatic cancer is higher than that of the healthy controls; furthermore, in the patients with Helicobacter pylori antibody positive, the infection rate of the Helicobacter pylori in the cytotoxin-associated gene A-negative strains of Helicobacter pylori is significantly higher than that of the healthy controls. Conclusions Helicobacter pylori infection is related to occurrence and development of pancreatic cancer. Specific mechanism is still not clarified and further research is need to study.

Citation： CAO Chengliang, QU Fengzhi, WANG Gang, SUN Bei. Research progress of role of Helicobacter pylori on oncogenesis and progression of pancreatic cancer . CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(10): 1275-1278. doi: 10.7507/1007-9424.201702019 Copy

1.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin, 2017, 67(1): 7-30.
2.	杜潇, 赵玉沛. 胰腺发育和胰腺癌中 Notch 信号通路作用的研究进展. 中国普外基础与临床杂志, 2010, 17(10): 1109-1112.0.
3.	王晓辉, 李非. 胰腺癌干细胞的研究进展. 中国普外基础与临床杂志, 2011, 18(9): 931-935.0.
4.	Jesnowski R, Isaksson B, Möhrcke C, et al. Helicobacter pylori in autoimmune pancreatitis and pancreatic carcinoma. Pancreatology, 2010, 10(4): 462-466.
5.	张德奎, 李玉民. 胰腺癌的内镜诊治进展. 中国普外基础与临床杂志, 2010, 17(10): 1027-1031.0.
6.	Becker AE, Hernandez YG, Frucht H, et al. Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. World J Gastroenterol, 2014, 20(32): 11182-11198.
7.	Cover TL. Perspectives on methodology for in vitro culture of Helicobacter pylori. Methods Mol Biol, 2012, 921: 11-15.
8.	Noto JM, Peek RM Jr. Helicobacter pylori: an overview. Methods Mol Biol, 2012, 921: 7-10.
9.	Engstrand L, Lindberg M. Helicobacter pylori and the gastric microbiota. Best Pract Res Clin Gastroenterol, 2013, 27(1): 39-45.
10.	Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984, 1(8390): 1311-1315.
11.	Alakkari A, Zullo A, O’Connor HJ. Helicobacter pylori and nonmalignant diseases. Helicobacter, 2011, 16 Suppl 1: 33-37.
12.	Venerito M, Vasapolli R, Malfertheiner P. Helicobacter pylori and gastric cancer: Timing and impact of preventive measures. Adv Exp Med Biol, 2016, 908: 409-418.
13.	Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol, 2015, 7(30): 2968-2979.
14.	Schulte A, Pandeya N, Fawcett J, et al. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes Control, 2015, 26(7): 1027-1035.
15.	Huang J, Zagai U, Hallmans G, et al. Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study. Int J Cancer, 2017, 140(8): 1727-1735.
16.	Chen XZ, Wang R, Chen HN, et al. Cytotoxin-associated gene A-negative strains of Helicobacter pylori as a potential risk factor of pancreatic cancer: A meta-analysis based on nested case-control studies. Pancreas, 2015, 44(8): 1340-1344.
17.	Chen XZ, Schöttker B, Castro FA, et al. Association of Helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: A ten-year follow-up of the ESTHER cohort study. Oncotarget, 2016, 7(13): 17182-17193.
18.	Bulajic M, Panic N, Löhr JM. Helicobacter pylori and pancreatic diseases. World J Gastrointest Pathophysiol, 2014, 5(4): 380-383.
19.	李庆东, 匡毅, 邓和军. 胰腺癌与幽门螺杆菌感染相关性研究. 中华医院感染学杂志, 2014, 24(23): 5861-5863.0.
20.	Venerito M, Vasapolli R, Rokkas T, et al. Helicobacter pylori and gastrointestinal malignancies. Helicobacter, 2015, 20 Suppl 1: 36-39.
21.	Ai F, Hua X, Liu Y. Preliminary study of pancreatic cancer associated with Helicobacter pylori infection. Cell Biochem Biophys, 2015, 71(1): 397-400.
22.	Risch HA, Yu H, Lu L, et al. ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study. J Natl Cancer Inst, 2010, 102(7): 502-505.
23.	Lindkvist B, Johansen D, Borgström A, et al. A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer. BMC Cancer, 2008, 8: 321.
24.	de Martel C, Llosa AE, Friedman GD, et al. Helicobacter pylori infection and development of pancreatic cancer. Cancer Epidemiol Biomarkers Prev, 2008, 17(5): 1188-1194.
25.	Risch HA, Lu L, Wang J, et al. ABO blood group and risk of pancreatic cancer: a study in Shanghai and meta-analysis. Am J Epidemiol, 2013, 177(12): 1326-1337.
26.	Lochan R, Daly AK, Reeves HL, et al. Family history of cancer and tobacco exposure in index cases of pancreatic ductal adenocarcinoma. J Oncol, 2011, 2011: 215985.
27.	Yeo TP, Lowenfels AB. Demographics and epidemiology of pancreatic cancer. Cancer J, 2012, 18(6): 477-484.
28.	Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinog, 2012, 51(1): 53-63.
29.	Cover TL, Peek RM Jr. Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer. Gut Microbes, 2013, 4(6): 482-493.
30.	Takayama S, Takahashi H, Matsuo Y, et al. Effects of Helicobacter pylori infection on human pancreatic cancer cell line. Hepatogastroenterology, 2007, 54(80): 2387-2391.
31.	陈佳慧, 肖江卫, 任明扬, 等. gastrokine 1 在胃癌组织中的表达及其与胃癌临床病理特征的关系.中国普外基础与临床杂志, 2012, 19(10): 1089-1093.0.
32.	Lee SW, Chang CS, Lee TY, et al. Risk factors and therapeutic response in Chinese patients with peptic ulcer disease. World J Gastroenterol, 2010, 16(16): 2017-2022.
33.	Sokic-Milutinovic A, Krstic M, Rozer-Smolovic B, et al. Role of Helicobacter pylori infection in gastroduodenal damage in patients starting NSAID therapy: 4 months follow-up study. Dig Dis Sci, 2010, 55(10): 2887-2892.
34.	葛均波, 徐永健. 内科学. 第 8 版. 北京: 人民卫生出版社, 2013.
35.	乔竹风. 胰腺癌与幽门螺杆菌感染相关性初步分析. 贵阳医学院学报, 2012, 37(4): 411-413.0.
36.	Risch HA. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst, 2003, 95(13): 948-960.
37.	Nilsson HO, Stenram U, Ihse I, et al. Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients. World J Gastroenterol, 2006, 12(19): 3038-3043.
38.	杨雷, 孙学军, 王炜, 等. MCP-1、VEGF 在胃癌中的表达与幽门螺旋杆菌感染的关系. 中国普外基础与临床杂志, 2009, 16(5): 375-378.0.
39.	李健. 胃肠间质瘤诊治的发展历程与方向. 中国普外基础与临床杂志, 2017, 24(2): 137-140.0.
40.	邓勇, 曾维琼, 詹柱, 等.幽门螺杆菌感染与胰腺癌相关性的累积 Meta 分析.重庆医学,2015,44(32):4549-45520.
41.	Rieder G, Karnholz A, Stoeckelhuber M, et al. H pylori infection causes chronic pancreatitis in Mongolian gerbils. World J Gastroenterol, 2007, 13(29): 3939-3947.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin, 2017, 67(1): 7-30.
2. 杜潇, 赵玉沛. 胰腺发育和胰腺癌中 Notch 信号通路作用的研究进展. 中国普外基础与临床杂志, 2010, 17(10): 1109-1112.0.
3. 王晓辉, 李非. 胰腺癌干细胞的研究进展. 中国普外基础与临床杂志, 2011, 18(9): 931-935.0.
4. Jesnowski R, Isaksson B, Möhrcke C, et al. Helicobacter pylori in autoimmune pancreatitis and pancreatic carcinoma. Pancreatology, 2010, 10(4): 462-466.
5. 张德奎, 李玉民. 胰腺癌的内镜诊治进展. 中国普外基础与临床杂志, 2010, 17(10): 1027-1031.0.
6. Becker AE, Hernandez YG, Frucht H, et al. Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. World J Gastroenterol, 2014, 20(32): 11182-11198.
7. Cover TL. Perspectives on methodology for in vitro culture of Helicobacter pylori. Methods Mol Biol, 2012, 921: 11-15.
8. Noto JM, Peek RM Jr. Helicobacter pylori: an overview. Methods Mol Biol, 2012, 921: 7-10.
9. Engstrand L, Lindberg M. Helicobacter pylori and the gastric microbiota. Best Pract Res Clin Gastroenterol, 2013, 27(1): 39-45.
10. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984, 1(8390): 1311-1315.
11. Alakkari A, Zullo A, O’Connor HJ. Helicobacter pylori and nonmalignant diseases. Helicobacter, 2011, 16 Suppl 1: 33-37.
12. Venerito M, Vasapolli R, Malfertheiner P. Helicobacter pylori and gastric cancer: Timing and impact of preventive measures. Adv Exp Med Biol, 2016, 908: 409-418.
13. Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol, 2015, 7(30): 2968-2979.
14. Schulte A, Pandeya N, Fawcett J, et al. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes Control, 2015, 26(7): 1027-1035.
15. Huang J, Zagai U, Hallmans G, et al. Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study. Int J Cancer, 2017, 140(8): 1727-1735.
16. Chen XZ, Wang R, Chen HN, et al. Cytotoxin-associated gene A-negative strains of Helicobacter pylori as a potential risk factor of pancreatic cancer: A meta-analysis based on nested case-control studies. Pancreas, 2015, 44(8): 1340-1344.
17. Chen XZ, Schöttker B, Castro FA, et al. Association of Helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: A ten-year follow-up of the ESTHER cohort study. Oncotarget, 2016, 7(13): 17182-17193.
18. Bulajic M, Panic N, Löhr JM. Helicobacter pylori and pancreatic diseases. World J Gastrointest Pathophysiol, 2014, 5(4): 380-383.
19. 李庆东, 匡毅, 邓和军. 胰腺癌与幽门螺杆菌感染相关性研究. 中华医院感染学杂志, 2014, 24(23): 5861-5863.0.
20. Venerito M, Vasapolli R, Rokkas T, et al. Helicobacter pylori and gastrointestinal malignancies. Helicobacter, 2015, 20 Suppl 1: 36-39.
21. Ai F, Hua X, Liu Y. Preliminary study of pancreatic cancer associated with Helicobacter pylori infection. Cell Biochem Biophys, 2015, 71(1): 397-400.
22. Risch HA, Yu H, Lu L, et al. ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study. J Natl Cancer Inst, 2010, 102(7): 502-505.
23. Lindkvist B, Johansen D, Borgström A, et al. A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer. BMC Cancer, 2008, 8: 321.
24. de Martel C, Llosa AE, Friedman GD, et al. Helicobacter pylori infection and development of pancreatic cancer. Cancer Epidemiol Biomarkers Prev, 2008, 17(5): 1188-1194.
25. Risch HA, Lu L, Wang J, et al. ABO blood group and risk of pancreatic cancer: a study in Shanghai and meta-analysis. Am J Epidemiol, 2013, 177(12): 1326-1337.
26. Lochan R, Daly AK, Reeves HL, et al. Family history of cancer and tobacco exposure in index cases of pancreatic ductal adenocarcinoma. J Oncol, 2011, 2011: 215985.
27. Yeo TP, Lowenfels AB. Demographics and epidemiology of pancreatic cancer. Cancer J, 2012, 18(6): 477-484.
28. Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinog, 2012, 51(1): 53-63.
29. Cover TL, Peek RM Jr. Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer. Gut Microbes, 2013, 4(6): 482-493.
30. Takayama S, Takahashi H, Matsuo Y, et al. Effects of Helicobacter pylori infection on human pancreatic cancer cell line. Hepatogastroenterology, 2007, 54(80): 2387-2391.
31. 陈佳慧, 肖江卫, 任明扬, 等. gastrokine 1 在胃癌组织中的表达及其与胃癌临床病理特征的关系.中国普外基础与临床杂志, 2012, 19(10): 1089-1093.0.
32. Lee SW, Chang CS, Lee TY, et al. Risk factors and therapeutic response in Chinese patients with peptic ulcer disease. World J Gastroenterol, 2010, 16(16): 2017-2022.
33. Sokic-Milutinovic A, Krstic M, Rozer-Smolovic B, et al. Role of Helicobacter pylori infection in gastroduodenal damage in patients starting NSAID therapy: 4 months follow-up study. Dig Dis Sci, 2010, 55(10): 2887-2892.
34. 葛均波, 徐永健. 内科学. 第 8 版. 北京: 人民卫生出版社, 2013.
35. 乔竹风. 胰腺癌与幽门螺杆菌感染相关性初步分析. 贵阳医学院学报, 2012, 37(4): 411-413.0.
36. Risch HA. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst, 2003, 95(13): 948-960.
37. Nilsson HO, Stenram U, Ihse I, et al. Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients. World J Gastroenterol, 2006, 12(19): 3038-3043.
38. 杨雷, 孙学军, 王炜, 等. MCP-1、VEGF 在胃癌中的表达与幽门螺旋杆菌感染的关系. 中国普外基础与临床杂志, 2009, 16(5): 375-378.0.
39. 李健. 胃肠间质瘤诊治的发展历程与方向. 中国普外基础与临床杂志, 2017, 24(2): 137-140.0.
40. 邓勇, 曾维琼, 詹柱, 等.幽门螺杆菌感染与胰腺癌相关性的累积 Meta 分析.重庆医学,2015,44(32):4549-45520.
41. Rieder G, Karnholz A, Stoeckelhuber M, et al. H pylori infection causes chronic pancreatitis in Mongolian gerbils. World J Gastroenterol, 2007, 13(29): 3939-3947.

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Research progress of role of Helicobacter pylori on oncogenesis and progression of pancreatic cancer

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