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find Keyword "事件相关电位" 13 results
  • 事件相关电位作为精神分裂症早期预测指标的研究进展

    精神分裂症的诊断目前依赖于临床表现,但临床表现往往缺乏特异性,且出现典型的临床表现需要经历较长时间。精神分裂症患者在出现典型精神病性症状之前,存在一个超高危的时期(UHR),对该时期患者的早期识别和干预可以获得相对较好的临床结局。事件相关电位(ERP)是客观评价大脑认知功能的重要方法,可早期发现精神分裂症患者的认知功能变化,根据ERP的一些特征性改变,可对处于UHR的患者是否会演变为精神分裂症进行早期预测。现结合近年研究,对ERP指标在精神分裂症UHR时期的变化及对精神分裂症的早期预测的价值进行综述。

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  • Early Signs of Cognitive Impairment in Patients with Obstructive Sleep Apnea Hypopnea Syndrome: An Event-Related Potential Study

    This study seeks to explore the early signs of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). According to polysomnography, twenty patients diagnosed with OSAHS and twenty normal controls underwent event-related potential (ERP) examination including mismatch negativity (MMN) and P300. Compared with normal controls, OSAHS patients showed significantly prolonged latency of MMN and P300 at Cz. After controlling age and body mass index (BMI), MMN latency positively correlated with apnea hypopnea index (AHI), oxygen reduction index, stage N1 sleep and arousal index, while MMN latency negatively correlated with stage N3 sleep and mean blood oxygen saturation; and P300 latency positively related to AHI and oxygen reduction index; no relationships were found among MMN latency, MMN amplitude, P300 latency and P300 amplitude. These results suggest that the brain function of automatic processing and controlled processing aere impaired in OSAHS patients, and these dysfunction are correlated with nocturnal repeatedly hypoxemia and sleep structure disturbance.

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  • Exploration on Electroencephalogram Mechanism Differences of Negative Emotions Induced by Disgusted and Sad Situation Images

    Evolutionary psychology holds such an opinion that negative situation may threaten survival, trigger avoidance motive and have poor effects on the human body function and the psychological quality. Both disgusted and sad situations can induce negative emotions. However, differences between the two situations on attention capture and emotion cognition during the emotion induction are still not well known. Typical disgusted and sad situation images were used in the present study to induce two negative emotions, and 15 young students (7 males and 8 females, aged 27±3) were recruited in the experiments. Electroencephalogram of 32 leads was recorded when the subjects were viewing situation images, and event-related potentials (ERP) of all leads were obtained for future analysis. Paired sample t tests were carried out on two ERP signals separately induced by disgusted and sad situation images to get time quantum with significant statistical differences between the two ERP signals. Root-mean-square deviations of two ERP signals during each time quantum were calculated and the brain topographic map based on root-mean-square deviations was drawn to display differences of two ERP signals in spatial. Results showed that differences of ERP signals induced by disgusted and sad situation images were mainly manifested in T1 (120-450 ms) early and T2 (800-1 000 ms) later. During the period of T1, the occipital lobe reflecting attention capture was activated by both disgusted and sad situation images, but the prefrontal cortex reflecting emotion sense was activated only by disgusted situation images. During the period of T2, the prefrontal cortex was activated by both disgusted and sad situation images. However, the parietal lobe was activated only by disgusted situation images, which showed stronger emotional perception. The research results would have enlightenment to deepen understanding of negative emotions and to explore deep cognitive neuroscience mechanisms of negative emotion induction.

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  • Study of Event related Brain Potential in Children with Attention Deficit Hyperactivity Disorder

    This study aims to explore the differences of event related potential (ERP) between attention deficit hyperactivity disorder (ADHD) and normal children, so that these differences provide scientific basis for the diagnosis of ADHD. Eight children were identified to be ADHD group by the diagnostic criteria of DSM IV (diagnostic and statistical manual of mental disorders IV), and the control group also consisted of 8 normal children. Modified visual continuous performance test (CPT) was used as the experiment paradigm. The experiment included two major conditions, i.e. Go and NoGo. All the 16 subjects participated in the study. A high density EEG acquisition instrument was used to record the EEG signal and processed these EEG data by means of ERP and spectrum analysis. P2 N2 peak peak value and spectral peak around 11 Hz were analyzed between ADHD subjects and those in the control group, and then statistical tests were applied to these two groups. Results showed that: ① Under the condition of Go, ADHD group had a significant lower P2 N2 peak peak value than the values in the control group ( P< 0.05); but under the condition of NoGo there was no significant difference in between. ② Compared with the control group, the ADHD group had significant lower spectral amplitude around 11 Hz under the condition of NoGo ( P< 0.05). However, under the condition of Go the difference was insignificant. In conclusion, there is certain cognitive dysfunction in ADHD children. P2-N2 peak-peak value and spectral peak around 11 Hz could be considered as clinical evaluation indexes of ADHD children′s cognitive function. These two objective indexes provide an early diagnosis and effective treatment of ADHD .

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  • Brain Efficient Connectivity Analysis of Attention Based on the Granger Causality Method

    The study of brain information flow is of great significance to understand brain function in the field of neuroscience. The Granger causality is widely used functional connectivity analysis using multivariate autoregressive model based on the predicted mechanism. High resolution electroencephalogram (EEG) signals of ten healthy subjects were collected with a visual selective attention task. Firstly, independent component analysis was used to extract three spatially independent components of the occipital, parietal, and frontal cortices. Secondly, the Granger causal connectivity was computed between these three regions based on the Granger causality method and then independent sample t-test and bootstrap were used to test the significance of connections. The results showed that Granger causal connectivity existed from frontal to occipital and from parietal to occipital in attentional condition, while causal connectivity from frontal to occipital disappeared in unattentional condition.

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  • Research on cortical cross-modal reorganization of children with congenital severe deafness after cochlear implant

    Cochlear implant (CI) is the only method for efficacious treatment of congenital severe deafness at present. However, for children with congenital severe deafness after CI, the mechanism of the structural and functional changes of their cerebral cortex is not clear. This study was based on the cross-modal reorganization of deaf patients. Event related potential (ERP) and source localization technique were used to visualize the change of cortical activity in children with congenital severe deafness during 1-year period (0, 1, 3, 6, 9 and 12 months after CI). We aimed to investigate the association between hearing restoration and cross-modal reorganization in children with congenital severe deafness after CI. The results showed that the cross-modal reorganization exists in children with congenital severe deafness. During hearing restoration, the function of the cross-modal reorganization reversed to the normal state. The method and conclusions of this study may be of significance in guiding the training and evaluation of hearing rehabilitation after CI in patients.

    Release date:2017-10-23 02:15 Export PDF Favorites Scan
  • The analysis of event-related potentials in normal brain aging based on N-back cognitive tasks

    The purpose of this study is to investigate the change of the whole brain event-related potentials(P300) in normal brain aging based on N-back cognitive tasks. The P300 of 15 normal young people and 10 normal old people were evaluated based on N-back cognitive tasks and analyzed. The results showed that the P300 latency of old people was longer in whole brain than young people, and amplitude was increased in the frontal-central region, while significantly increased in the pre-frontal region in the same load cognitive tasks. With the cognitive task load increasing, the amplitude of old people in high-load task was higher in the whole brain than that in low-load task, mainly in in the frontal region, but the difference was not statistically significant. The latency in the high-load task was shorter in the frontal-central region of right brain than the low-load task, and the difference was statistically significant. Thus, P300 showed that the normal brain aging process is mainly reflected in the pre-frontal region, and the high-load cognitive task could better reflect the change of brain function compared with the low-load cognitive task. The finding is of revelatory meaning for diagnosis of early dementia in patients.

    Release date:2017-12-21 05:21 Export PDF Favorites Scan
  • An event-related potential objective evaluation study of mental fatigue based on 2-back task

    The electroencephalographic characteristics of mental fatigue, which was induced by long-term working memory task of 2-back, were studied by event-related potential (ERP) technology in order to obtain objective evaluation indicators for mental fatigue. Thirty-two healthy male subjects, 22–28 years old, were divided into two groups evenly, one is un-fatigue group and the other is fatigue group. The fatigue group performed a 2-back task for 100 min continuously, while the un-fatigue group just performed a 2-back task at the first and last 10 min respectively, and rested during the middle 80 min. The subjective levels of fatigue, task performance and electroencephalogram were recorded. The impaired thought and attention states, enhanced sleepy and fatigue feeling were found in the fatigue group, meanwhile their reaction time to 2-back task extended, and the accuracy decreased significantly. These results verified the validity of mental fatigue model induced by 2-back task, and then the ERP characteristic parameters were compared and analyzed between fatigue group and un-fatigue group. The results showed that the fatigue group’s amplitudes of P300 (F = 2.539, P < 0.05) and error-related negativity (ERN) ( F = 10.040, P < 0.05) decreased significantly along with the increase of fatigue comparing with the un-fatigue group, however, there were no significant change in other parameters (all P > 0.05). These results demonstrate that P300 and ERN can be considered as potential evaluation indictors for mental fatigue induced by long-term working memory task, which will provide basis for the future exploring of countermeasure for mental fatigue.

    Release date:2019-02-18 02:31 Export PDF Favorites Scan
  • Study of neural mechanisms underlying anisometropic amblyopia with event-related potential

    ObjectiveTo investigate the neural mechanisms of subjects with anisometropic amblyopia using event-related potential (ERP) technology.MethodsNineteen subjects diagnosed with anisometropic amblyopia were consecutively recruited from the outpatients of the West China Hospital of Sichuan University from June 2013 to February 2014, and twenty normal subjects were recruited as control subjects. All subjects were given different orientation Gabor stimuli with three spatial frequencies (1, 2, 8 cpd) and their ERP was recorded. The differences of P3b, including amplitude and latency, were compared between amblyopic eye and fellow or control eye.ResultsAmong the three groups of amblyopic eye and fellow or control eye, there was no statistically significant difference in accuracy or response time at three spatial frequencies (P>0.05), in latency or amplitude of P3b at low spatial frequencies (1, 2 cpd) ((P>0.05), or in amplitude of P3b at high spatial frequency (8 cpd) (P>0.05). P3b latency of amblyopic eye extended at high spatial frequency (8 cpd), compared to fellow or control eye. Amblyopic eye was most significantly weakened in Brodmann area 17 at the P3b wave of each spatial frequency (1, 2, 8 cpd), and there was most significantly weakened in high spatial frequency (8 cpd).ConclusionThe P3b latency of amblyopic eye extended at high spatial frequency suggests that the cognitive function of amblyopia is impaired, at an extent, in the late visual processing stage.

    Release date:2019-12-12 04:12 Export PDF Favorites Scan
  • Electroencephalogram characteristics under successful cognitive reappraisal in emotion regulation

    Cognitive reappraisal is an important strategy for emotion regulation. Studies show that even healthy people may not be able to implement this strategy successfully, but the underlying neural mechanism behind the behavioral observation of success or failure of reappraisal is unclear. In this paper, 28 healthy college students participated in an experiment of emotional regulation with the cognitive reappraisal strategy. They were asked to complete the cognitive psychological questionnaires before the experiment. Their behavioral scores and scalp electroencephalogram (EEG) signals were collected simultaneously during the experiment. We divided all the subjects into two groups, according to the statistical test of valence scores. Then we analyzed their questionnaires, early event-related potential (ERP) components N200, P200, and late positive potential (LPP), and calculated the correlation between the valence score and the amplitude of LPP. The results showed that, in both groups, compared with negative-watching, the reappraisal induced larger N200 and P200 components and there were two modulation patterns (“increase” and “decrease”) of the reappraisal effect on the amplitude of early LPP (300−1 000 ms after stimulus onset). Moreover, correlation analysis showed that significant positive correlation between two differences in the successful group, i.e., the greater difference in the valence scoresin between reappraisal and negative-watching, the greater difference in the amplitude of early LPP between reappraisal and negative-watching; but no such effect was found in the failure group. These results indicated that, whether reappraisal was successful or not, no significant effect on early ERP components was found; and there were different patterns of the reappraisal effect on early LPP. The difference between successful and failure groups was mainly reflected in early LPP, that is, the EEG characteristics and behavioral scores of successful group were significantly positively correlated. Furthermore, the small sample analysis showed that this correlation only existed in the pattern of "increase". In the future, more research of this modulation mode is necessary in order to find more stable EEG characteristics under successful cognitive reappraisal in emotion regulation.

    Release date:2020-10-20 05:56 Export PDF Favorites Scan
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