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find Keyword "共患病" 14 results
  • Epidemic Survey Echinococcosis for Human and Livestock in ABa Prefecture of Sichuan Province of Year 2008

    Objective To survey and analyze the epidemiological and distribution situation of echinococcosis for human and livestock in Aba Prefecture of Sichuan Province. Methods According to the Standard WS257-2006 of Diagnose Hydatidosis which was published by the WHO, the residents from 141 countrysides of 13 counties where echinococcosis prevailed were examined by B-ultrasound. Sera anti-echinococcosis IgG of children under 12 years old and dejecta-antigen of dogs were examined by ELISA. Visceral of yaks and sheep were examined in slaughter places to make sure their infection. Results Human surveillance: 48 288 people were examined by B-ultrasound, 470 of which were patients. The positive rate was 0.97%; 19 people was Alveolar Echinococcus, and 451 people was Cystic Echinococcus. Sera of 5 372 children was examined, 358 of which were positive. The positive rate was 6.67%. Livestock surveillance: 5814 dejecta-antigens of dogs were examined, 989 of which were positive. The positive rate was 17.01%. 3 336 yaks and sheep were examined, 113 of which were positive. The rate was 3.39% (113/3 336). Conclusion Alveolar and Cystic Echinococcus exist and prevail among humans and cattles in Aba Prefecture of Sichuan Province, with a larger proportion of Cystic Echinococcus.

    Release date:2016-08-25 02:51 Export PDF Favorites Scan
  • CLINICAL XENOTRANSPLANTATION: CURRENT PROGRESS, PROBLEMS AND SOLUTIONS

    Xenotansplantation has become a global focus because it may solve the formidable problems in allotransplantation, that is, the donor source. Hitherto clinical xenotransplantion has been in the stage of research with limited cases and unsatisfactory results. The difficulties which hinder the progress of xenotransplantation include: the ideal animal donor has not been found, it is rather difficult to control the rejections (hyperacute rejection, acute vascular rejection, perhaps acute cellular rejection and chronic rejection) after xenotransplantation compared with those after allotransplantation, some animal diseases might be transmitted to and do harm to human recipients, even the community. It is still unknown whether the functions of animal organs can substitute those of human organs permanently. Transgenic pigs on research and various measurements to suppress humoral and cellular immunity may be helpful in overcoming the problems of xenogeneic rejections. Animal diseases should be prevented, screened and treated, and animal models should be established to study the possibility of satisfactory working of animal organs in human body before clinical xenotransplantation is widely practised.

    Release date:2016-09-01 11:07 Export PDF Favorites Scan
  • 癫痫躯体共患病的研究进展

    癫痫是最常见的慢性神经系统疾病之一,随着癫痫研究的深入,癫痫共患病引起了人们的广泛关注。目前,癫痫精神行为共患病(如焦虑、抑郁、注意缺陷多动障碍、自闭症、精神发育迟滞、精神性厌食症、双相障碍、情绪障碍等)和神经系统共患病(如偏头痛、痴呆、阿尔茨海默病、中风、帕金森病、睡眠障碍、脑肿瘤、脑病等)已有许多报道,在此不再赘述。近年来,癫痫合并躯体共患病的报道越来越多,应当给予足够重视,现就癫痫躯体共患病研究进展做一综述。

    Release date:2018-07-18 02:17 Export PDF Favorites Scan
  • Clinical analysis of 102 Tibetan epilepsy patients comorbid with depression, anxiety, depression and anxiety

    Objectives To analyze the prevalence and clinical features of depression, anxiety, depression and anxiety in Tibetan patients with epilepsy and to improve the diagnosis and treatment. Methods 102 patients with epilepsy, who had been admitted to the Department of Neurology of the People's Hospital of Tibet Autonomous Region from January 2017 to December 2017, were diagnosed according to the Chinese Standard Classification and Diagnostic Criteria for Mental Disorders (3rd Edition) (CCMD-3). The Hamilton depression scale (HAMD 24 items) and the Hamilton anxiety scale (HAMA 14 items) were used to measure depression and anxiety. Different genders, ages, durations, frequency of attacks, and seizures types were analyzed for depression, anxiety, depression and anxiety. Univariate analysis was used to screen the factors that may cause depression, anxiety, depression and anxiety in patients with epilepsy. Logistic regression was used to analyze the risk factors of depression, anxiety, depression and anxiety in patients with epilepsy. Results Among the 102 patients with epilepsy, 35 (34.31%) comorbid depression, 10 (9.80%) comorbid anxiety, and 54 (52.94%) comorbid depression and anxiety. Univariate analysis showed that there was a significantly statistical difference in the duration of the disease and the frequency of seizures in local patients with epilepsy (P<0.05). There was a statistically significant difference in the frequency of epileptic seizures and anxiety (P<0.05). Multivariate logistic regression analysis showed that the probability of anxiety in patients with a disease duration of ≤2 years was only 10.1% of those with a course >2 years [OR=0.101, 95%CI (0.012, 0.915), P<0.05]; and the frequency of seizures was not an risk factors for epileptic comorbid with anxiety (P>0.05). The rate of depression and anxiety in patients with seizure frequency >2 times per month was 4.853 times higher than that of patients with seizure frequency ≤2 times per month [OR=4.853, 95%CI (2.024, 11.634), P<0.05]. Conclusions Tibetan patients with epilepsy have a high prevalence of depression, anxiety, depression and anxiety. In the diagnosis and treatment, we should strengthen the understanding and provide the appropriate prevention and treatment to improve the diagnosis and treatment level.

    Release date:2018-09-18 10:17 Export PDF Favorites Scan
  • Present situation and risk factors of comorbidity in adult epilepsy patients in West China

    ObjectiveTo explore the status of common comorbidities in adult epilepsy patients in western China, and to explore the related risk factors.MethodsThe Chinese version of Generalized Anxiety Disorder (GAD)-7, neurological disorders depression inventory for epilepsy (NDDI-E) scales, pittsburgh sleep quality index scale (PSQI) and epworth sleepiness scale (ESS) were used to evaluate the 199 epilepsy patients between April 2017 and March 2018 in the Epilepsy Center of Neurology Department of Sichuan People's Hospital. Logistic regression analysis was performed on the risk factors of epilepsy comorbidity.ResultsIn the 199 adult epilepsy patients, 28.1% had anxiety, 17.1% had depression, 33.2% had sleep disorder, and 2.5% had migraine. 140 patients received monotherapy, including 15 patients with carbamazepine (CBZ), 20 patients with lamotrigine (LTG), 26 patients with levetiracetam (LEV), 31 patients with topiramate (TPM), 25 patients with oxcarbazepine (OXC), and 23 patients with Valproate (VPA).Multivariate logistic regression analysis of epilepsy patients treated with monotherapy showed that seizure occurring more than once a month, LEV, TPM, sleep disorders were independent risk factors for anxiety in patients with epilepsy (P<0.05). Unemployment, seizure occurrence in the last three months, sleep disorders were independent risk factors for comorbid depression (P<0.05). Anxiety, depression, daytime sleepiness, CBZ, LTG were independent risk factors for comorbid sleep disorders (P<0.05).ConclusionsAnxiety, depression and sleep disorder are common comorbidities in adults with epilepsy in westChina. For patients with affective disorder and sleep disorder, early identification and intervention may be important to improve the quality of life and prognosis of patients. In addition, patients treated with LEV or TPM monotherapy had a higher risk of anxiety than other drugs. Patients with LTG and CBZ monotherapy are more likely to comorbid sleep disorders.

    Release date:2019-07-15 02:48 Export PDF Favorites Scan
  • 成人癫痫与抑郁

    癫痫作为神经系统的常见慢性疾病已经成为一个全球健康问题,癫痫共患病的存在进一步恶化了癫痫的结局,加剧了不良社会后果。抑郁障碍是癫痫最常见共患病,并导致癫痫患者对抗癫痫药物的耐受性低、服药依从性低、治疗效果差、生活质量下降、认知障碍增加、其他慢性疾病和自杀的风险增加等一系列不良后果,进一步恶化了癫痫的结局。目前,癫痫共患抑郁存在着高发病率、低诊断率、低治疗率的现状,癫痫共患抑郁的筛查、评估和管理应成为癫痫临床不可或缺的组成部分。

    Release date:2020-03-20 08:06 Export PDF Favorites Scan
  • 癫痫共患孤独症谱系障碍的分子遗传学研究进展

    癫痫与孤独症谱系障碍(Autism spectrum disorder,ASD)是十分常见的具有高共患病几率的两组神经系统疾病。近年来,癫痫-ASD 共患病的发病率高于癫痫与 ASD 单独的发病率,且癫痫 ASD 共患病的发病率逐年升高,提示癫痫与 ASD 之间存在相关性,引起了人们的广泛重视。目前对癫痫-ASD 共患病的研究有限,其发病原因及具体机制尚不明确。已知的癫痫和 ASD 病例中约半数具有遗传基础。染色体检查、全基因组、外显子组测序加深了临床对癫痫-ASD 共患病的分子遗传学病因的认识。此文总结了癫痫-ASD 共患病常见的 3 种染色体异常和 17 种基因突变,从分子遗传学角度结合临床症状、体征、辅助检查等深入探讨,了解该共患病的共同遗传基础。

    Release date:2020-09-04 03:02 Export PDF Favorites Scan
  • 癫痫共患注意缺陷多动障碍发病机制的研究进展

    大量高质量临床研究显示,虽然癫痫和注意缺陷多动障碍(Attention-deficit hyperactivity disorder,ADHD)为独立疾病,但二者可能存在共同的发病机制,影像学的不断发展及大脑网络功能测定技术的兴起进一步支持了该假设,快点燃及匹鲁卡品诱导的癫痫动物模型为研究二者共病机制提供了基础,去甲肾上腺素能通路的分子机制研究为探索治疗新靶点提供了方向。文章对近年来关于癫痫共患 ADHD 发病机制的研究作一综述,以期为相关疾病的临床诊治提供一定参考。

    Release date:2020-09-04 03:02 Export PDF Favorites Scan
  • 癫痫与糖尿病的相关性研究进展

    随着糖尿病(Diabetes mellitus,DM)和癫痫患病率的不断增加,两者共病的现象已不少见,且大量流行病学调查显示,DM 和癫痫存在相关性。目前,国内外对于癫痫共病 DM 的认识仍不充分。本文就流行病学、基因层面、DM 促进癫痫发病的机制以及两者分别与相关疗法或药物之间的关系等方面对癫痫和 DM 的相关性展开综述,并总结文献对癫痫共病 DM 的治疗提出建议,为早期识别和防治提供依据。

    Release date:2021-06-24 01:26 Export PDF Favorites Scan
  • Analysis of clinical features of epilepsy comorbid with tic disorders in children

    ObjectiveTo summarize the clinical characteristics of epilepsy comorbid with tic disorders in children, and discuss its diagnosis, treatment and management. MethodsThe clinical data of 12 epileptic children comorbid with tic disorders treated in Wuhan children's Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology from December, 2018 to June, 2021 was collected retrospectively. The clinical characteristics, EEG, MRI, treatment, prognosis of epileptic children comorbid with tic disorders were analyzed and summarized. ResultsThere were 12 epileptic children comorbid with tic disorders in total, 11 males, 1 female, average (10.0±2.9) years old. The onset age of epilepsy was ranged from 0.6 to 11 years old, average (6.5±3.3) years old. The onset age of tic disorders ranged from 3.5 to 11 years old, average (7.2±2.0) years old. The epileptic seizure types included focal seisures (Focal, 8 cases), atypical absence seizures(AAS, 2 cases), myoclonic seizure (MS, 1 case), generalized tonic-clonic seisures (GTCS, 3 cases). The epileptic syndromes included benign epilepsy with centrotemporal spikes (BECT, 2 cases), Dravet syndrome (1 case), juvenile myoclonic epilepsy(JME, 1 case), temporal lobe epilepsy (TLE, 1 case).The average oral antiepileptic seizure drug was 1, including lamotrigine(LTG), valproic acid(VPA), oxcarbazepine(OXC), levetiracetam(LEV), topiramate(TPM) and Perampanel. The clinical course of tic disorders ranged from 0.5 to 3.0 years, average (1.5±0.9) years. The clinical types included provisional tic disorder (PTD, 4 cases), chronic tic disorder (CTD, 5 cases, all of which were motor tics) and Tourette syndrome (TS, 3 cases). The severity of tic disorders was mild up to the last follow-up. In addition to tic disorders, other comorbidities included attention deficit and hyperactivity disorder (ADHD, 2 cases), 1 children was mixed type, 1 children was hyperactive impulse dominated type, psychomotor development disorder(3 cases), enuresis (1 case) and emotional disorder (1 case). There were interictal epileptiform discharges in 12 children with EEG, including focal discharges(7 cases, 1 EEG showed that focal discharges originated from the right temporal region), multiple discharges (5 cases, 1 EEG showed that multiple discharges originated from the right centro-temporal region), and clinical seizures were monitored in 6 cases (3 cases of focal seizures, 2 cases of atypical absence seizures, and 1 case of myoclonic seizure). Magnetic resonance imaging (MRI) of head showed no obvious abnormalities. The follow-up time was ranged from 0.5 to 3.0 years. Up to the last follow-up (2022.01.01), 8 cases of epilepsy had been controlled and 4 cases of tic disorders were cured. The prognosis of epilepsy comorbid with tic disorders in most children was good. ConclusionsThe prognosis of epilepsy comorbid with tic disorders in most children is good, the types of epileptic seizures and epileptic syndromes are various. Prognosis of these chidren mainly depends on the control of epileptic seizures, the severity of tics and existence of other neuropsychiatric comorbidities. Therefore, drug treatment mainly focuses on controlling the epileptic seizures, and the impact of comorbidities on children can not be ignored. The clinical management needs regular follow-up, timely evaluation and corresponding interventions.

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