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find Author "张燕玲" 9 results
  • The Effects of Somatostatin Analog on the Apoptosis and the Expression of cmyc Protein of Hepatocellular Carcinoma Cell

    ObjectiveTo investigate the effects of somatostatin8 (SS8) on the apoptosis and the expression of cmyc protein of hepatocellular carcinoma cell SMMC7721. MethodsCultured in vitro, hepatocellular carcinoma cells SMMC7721 were incubated with SS8 (10 μg/ml). The apoptosis rate and expression of cmyc protein were detected by flow cytometry (FCM). ResultsSS8 can cause the spanonumber in S and G2/M phase and the auxonumber in G0/G1 phase of SMMC7721 cells . The apoptosis rate was 14.2% in the study group and 6.1% in the control group, and there was significant difference (P<0.05); The level of expressions of cmyc protein was 0.833±0.035 after action by SS8 for 24 h. Compared with control group, there was no significant difference in the study group(P>0.10).But after the cells were incubated with SS8 for 48,72,96,120,144 h, the level of expressions of cmyc protein was 0.818±0.04,0.721±0.029,0.669±0.026,0.648±0.045,0.642±0.028 respectively in the study group, and there was significant difference as compared with the control group (P<0.05). Conclusion The SS8 can induce the apoptosis and lower expression of cmyc protein of hepatocellular carcinoma cell SMMC7721.

    Release date:2016-08-28 04:47 Export PDF Favorites Scan
  • 高血压合并糖尿病的治疗方法选择

    Release date:2016-08-25 03:16 Export PDF Favorites Scan
  • 慢性阻塞性肺病急性加重期的循证治疗

    Release date:2016-08-25 03:16 Export PDF Favorites Scan
  • Treatment of post-operative limited small cell lung cancer

    Release date:2016-08-25 03:17 Export PDF Favorites Scan
  • 慢性阻塞性肺病稳定期的治疗方法

    Release date:2016-08-25 03:17 Export PDF Favorites Scan
  • Treating chronic heart dysfunction based on evidence

    Release date:2016-08-25 03:17 Export PDF Favorites Scan
  • Evidence of Preventing Infections in Nephrotic Syndrome

    Objective To review the efficacy and safety of interventions for preventing infections in nephrotic syndrome using evidence-based principles for clinicians to practice easily. Methods We searched Cochrane controlled trials register database, MEDLINE, EMBASE and Chinese Biologic Medical database. Results Total 11 articles were obtained including RCTs, non-controlled clinical studies and traditional narrative reviews. No systematic review or meta-analysis was identified. Prophylactic interventions for reducing risks of infection in nephrotic syndrome included intravenous immunoglobulin, thymosin, traditional Chinese herb, lamivudine, pneumococcal vaccination and chemoprophylaxis. Conclusion At present, the studies about interventions for preventing infection in nephrotic syndrome were limited in quantity and poor in the quality of methodology, therefore, the promising conclusions were unavailable. Rigid randomized placebo-controlled clinical trials with blinding or systematic review or meta-analysis would be very necessary for further assessing the efficacy and safety of the prophylactic interventions for preventing infections in nephrotic syndrome

    Release date:2016-08-25 03:33 Export PDF Favorites Scan
  • Evidence-Based Treatment for a Patient of Stage T2N0M0 Stomach Sinus Cancer

    Stomach cancer is a malignancy arising from the stomach mucous epithelium. It accounts for 95% of all stomach malignancy cancer. The prevalence of stomach cancer is high in China and the treatment is debated, especially regarding choice of chemotherapy and treatment duration. In order to identify the best treatment and follow-up for patient with stage T2N0M0 stomach sinus cancer, we searched MEDLINE, SUMsearch, The Cochrane Library (Issue 4, 2004), Clinical Evidence (Issue 4, 2003) and CBMdisc (1981 to 2004). A total of 3 systematic reviews, 28 randomized controlled trails, 3 cohort studies and 3 observational studies were identified. We evaluated the quality of included studies.All studies were divided into 5 grades by the levels and grades of recommendation. We drew a conclusion by synthesizing the results of included studies: The primary treatment for the patient was surgery treatment including gastric deuto-total resection and D1 lymph node dissection. There was no evidence supporting chemotherapy use in either systematic or abdominal cavity after surgery. The survival rate was high in 5 years and 10 years, so the follow-up time should not be long and the follow-up infermission should not less than 1 year. Follow-up included the dynamic and delayed MR sequence with Gd-DTPA, the level of serum CA199, endoscope, and stool occult blood test.

    Release date:2016-09-07 02:25 Export PDF Favorites Scan
  • Evidence-Based Medicine in USA : Current Application and Practice

    Based on the site visit on the current application and practice of evidence-based medicine in USA, we find the difference between China and USA so as to further promote and plan the development of evidence-based medicine in China.

    Release date:2016-09-07 02:25 Export PDF Favorites Scan
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