Ischemic stroke (IS) is one of the important diseases threatening human health. The occurrence and development of IS can trigger a series of complex pathophysiological changes, including damage to the blood-brain barrier, ion imbalance, oxidative stress, mitochondrial damage, which ultimately lead to the apoptosis and necrosis of nerve cells in the ischemic area. Impaired blood-brain barrier is a key factor for cerebral edema, hemorrhagic transformation and poor prognosis in patients with IS, and neuroinflammatory response plays an important role in the damage and repair of the blood-brain barrier. This article mainly focuses on the neuroinflammatory response mediated by glial cells, pro-inflammatory cytokines and matrix metalloproteinases and the related mechanisms of IS blood-brain barrier damage and repair, in order to provide new directions for the treatment of IS.
Objective To summarize the current status and hotspots of research on obesity and neuroinflammation in the last decade through bibliometric analysis. Method Web of Science database was searched for English literature on obesity and neuroinflammation published between 2011 and 2021. The CiteSpace software was applied to analyze the number of publications, authors, institutions, countries and collaborations, and keywords in the field of obesity and neuroinflammation research.Results A total of 548 articles were included, and the number of articles had been increasing year by year. The top three countries in the field of obesity and neuroinflammation research were the United States, China, and Brazil. University of Toronto was the core research institution. Keywords formed 16 clusters, and there were a total of 15 emergent words.Conclusions Over the past decade, research on obesity and neuroinflammation has shown an upward trend. The research hotspots in the field of obesity and neuroinflammation mainly focus on insulin resistance, obesity, Alzheimer’s disease, high fat diet, inflammation, neuroinflammation, and other aspects. The prefrontal cortex and memory impairment are future hotspots.